Browse the latest research summaries in the field of gastroenterology for spinal cord injury patients and caregivers.
Showing 81-90 of 136 results
Journal of Clinical Medicine, 2021 • March 1, 2021
The study validated the MENTOR tool in a Japanese rehabilitation setting for individuals with SCI or spina bifida suffering from NBD. The results showed acceptable concordance between the MENTOR tool'...
KEY FINDING: The MENTOR tool showed acceptable concordance with physician decisions regarding treatment adequacy and the need for treatment change.
Biology, 2021 • March 24, 2021
In the present study, we aimed to determine whether the mental state of FMT donor rats would influence the therapeutic benefits of FMT after SCI. Contrary to our hypothesis, FMT from anxious donors did ...
KEY FINDING: Fecal transplant from uninjured donor rats with increased anxiety-like behaviour was not only ineffective in preventing injury-induced microbiota changes, but it also increased intestinal permeability and anxiety-like behaviour of the recipient rats.
Journal of Spinal Cord Medicine, 2021 • January 1, 2021
This clinical practice guideline (CPG) focuses on the management of neurogenic bowel dysfunction (NBD) in adults after spinal cord injury (SCI). The CPG offers recommendations on assessment, basic bow...
KEY FINDING: A basic bowel management (BBM) program should be used for both reflexic and areflexic NBD.
J. Clin. Med., 2021 • April 9, 2021
This systematic review aimed to assess the composition of the gut microbiota in patients with SCI or MS compared to healthy controls, considering the potential roles of neurogenic bowel function, diet...
KEY FINDING: The review found that alpha diversity in chronic SCI patients might be lower compared to healthy controls, while alpha diversity in MS patients might be similar or lower.
Journal of Clinical Medicine, 2021 • April 14, 2021
This study investigated the impact of inpatient rehabilitation on bowel dysfunction in individuals with acute traumatic/non-traumatic SCI, focusing on the use of laxatives and opioids. The research fo...
KEY FINDING: There was an increase in the frequency of bowel movements and a decrease in the frequency of fecal incontinence from admission to discharge.
Neurotrauma Reports, 2020 • January 1, 2020
This study demonstrates that functional motor and enteric neuroplastic changes affect preferentially the proximal colon compared with the distal colon. Using a rat model of chronic thoracic SCI, we de...
KEY FINDING: The contractile response to bethanechol was significantly decreased in the proximal colon of SCI rats but not in the distal colon.
Frontiers in Microbiology, 2022 • September 26, 2022
This study aimed to investigate the changes in lymphocyte subsets and gut microbiota in Chinese Han patients with SCI. It enrolled 23 SCI patients and 21 healthy controls, collecting blood and fecal s...
KEY FINDING: CD4 + cells, CD4 + /CD8 + ratio and CD4 + CD8 + cells in peripheral blood of SCI patients were significantly lower than those of the control group.
Frontiers in Rehabilitation Sciences, 2022 • October 26, 2022
This study measured the gut microbiome in the first three weeks of rehabilitation following stroke and its associations with leaky gut markers, dietary intake, and functional recovery measures. The re...
KEY FINDING: Stroke patients had significantly lower abundances of butyrate producers, secondary bile acid producers, equol producers, and sulfate reducers in their gut.
Mediators of Inflammation, 2023 • February 8, 2023
This evidence mapping summarizes associations of gut microbiota with neurological or psychiatric disorders, identifying common or differential gut microbiota present in different disorders, which may ...
KEY FINDING: Many studies have investigated the link between gut microbiome alpha diversity and disease, with the Shannon and Simpson indices being the most studied.
Molecular Brain, 2023 • February 5, 2023
This study examined the gut microbiota and serum metabolites in SCI patients compared to healthy individuals to understand their interaction in SCI pathogenesis. We present a comprehensive landscape o...
KEY FINDING: SCI patients have different gut bacteria compared to healthy people, with increases in some bacteria (UBA1819, Anaerostignum, Eggerthella, Enterococcus) and decreases in others (Faecalibacterium, Blautia, Escherichia–Shigella, Agathobacter, Collinsella, Dorea, Ruminococcus, Fusicatenibacter, and Eubacterium).