Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 91-100 of 217 results
Top Spinal Cord Inj Rehabil, 2021 • January 1, 2021
Spinal cord injury (SCI) results in dramatic changes in body composition, with lean mass decreasing and fat mass increasing in specific regions that have important cardiometabolic implications. The re...
KEY FINDING: SCI leads to regionally specific changes in body composition, with increased adiposity around the viscera, skeletal muscle, and bone marrow.
Top Spinal Cord Inj Rehabil, 2021 • January 1, 2021
Persons with SCI are at high risk for developing neurogenic obesity due to muscle paralysis and obligatory sarcopenia, sympathetic blunting, anabolic deficiency, and blunted satiety. Upper limb utiliz...
KEY FINDING: Obesity and increased weight are significant contributors to upper extremity overuse injuries in persons with SCI.
Top Spinal Cord Inj Rehabil, 2021 • January 1, 2021
A traumatic injury to the spinal cord causes an immediate cascade of inflammatory responses that, among other things, can initiate hypersensitivity within nociceptive pathways leading to chronic neuro...
KEY FINDING: Higher BMI is associated with greater pain severity in persons with chronic SCI, irrespective of the type of pain.
Top Spinal Cord Inj Rehabil, 2021 • January 1, 2021
This article reviews the relationship between sleep-disordered breathing (SDB) and neurogenic obesity in adults with spinal cord injury (SCI). It highlights the increased risk of metabolic syndrome, o...
KEY FINDING: Adults with spinal cord injury (SCI) are at a higher risk of disorders related to metabolic syndrome, including sleep-disordered breathing (SDB).
Top Spinal Cord Inj Rehabil, 2021 • January 1, 2021
Obesity is a common cardiometabolic risk factor in SCI, and exercise is a primary treatment strategy. However, tailoring exercise to manage obesity in SCI requires careful consideration of the reduced...
KEY FINDING: SCI leads to reduced muscle mass and decreased oxidative capacity, limiting the effectiveness of exercise in creating a calorie deficit.
International Journal of General Medicine, 2021 • March 16, 2021
This study evaluated bone mineral density (BMD) changes at the distal femur (DF) and proximal tibia (PT) in spinal cord injury (SCI) patients during the first year after injury. The BMDs at the DF and...
KEY FINDING: BMD at the DF, PT, and hip were significantly lower in SCI patients than in controls.
Frontiers in Endocrinology, 2021 • May 11, 2021
This study investigated the impact of spinal cord injury (SCI) on FGF21 and adiponectin signaling in mice, focusing on liver, adipose tissue, and skeletal muscle. The findings indicated that SCI reduc...
KEY FINDING: SCI reduced serum FGF21 levels and hepatic FGF21 expression, as well as b-klotho and FGF receptor-1 (FGFR1) mRNA expression in adipose tissue.
Neurotrauma Reports, 2020 • January 1, 2020
This study examined the effects of a high-fat diet (HFD) on glucose tolerance, tissue mass, and bone after spinal cord injury (SCI) in mice. SCI mice fed a HFD showed glucose intolerance, reduced musc...
KEY FINDING: SCI animals display signs of glucose intolerance at 84 days after initiating HFD despite a decrease in body mass and lower iFAT, eFAT, and oFAT masses.
Neurotrauma Reports, 2021 • January 1, 2021
This retrospective cohort study examined the potential effects on outcomes of hyperglycemia in the hyperacute stage after acute traumatic SCI. Hyperglycemia diagnosed at day 7 post-injury was associat...
KEY FINDING: Hyperglycemia at day 7 post-injury was associated with significantly greater mortality rates within the first year after acute traumatic SCI.
J. Funct. Morphol. Kinesiol., 2022 • October 17, 2022
This study investigates the effect of low force electrically induced exercise (LFE) on postprandial glycemic markers in individuals with spinal cord injury (SCI). The results indicate that LFE attenua...
KEY FINDING: People with SCI had higher fasting insulin, lactate, C-reactive protein, uric acid, alkaline phosphatase, and low-density lipoprotein compared to the non-SCI population.