Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 81-90 of 217 results
Frontiers in Endocrinology, 2020 • April 15, 2020
This review comprehensively characterizes available treatment options targeting the skeleton and bone in the setting of SCI. Pharmacological interventions such as bisphosphonates and anti-sclerostin m...
KEY FINDING: Bisphosphonates, anti-sclerostin monoclonal antibodies, hydrogen sulfide, parathyroid hormone, and RANKL pathway inhibitors are valuable options for treating bone alterations after SCI.
Neurobiol Dis, 2020 • July 1, 2020
This study investigates the impact of a Western diet on the adult mouse spinal cord and its response to traumatic injury. Findings show that systemic insulin resistance is reflected in abnormalities i...
KEY FINDING: A Western diet impairs insulin signaling and energy homeostasis in the spinal cord, even before injury.
AACE Clinical Case Reports, 2020 • May 1, 2020
This case report describes a type 1 diabetic patient who developed tetraplegia and experienced a massive increase in subcutaneous insulin requirements. Treatment with pramlintide led to a significant ...
KEY FINDING: The patient's subcutaneous insulin requirements increased dramatically to 600 U/day after spinal cord injury, compared to 81 U/day before the injury.
Top Spinal Cord Inj Rehabil, 2021 • January 1, 2021
Physiological changes in adipose tissue following SCI should be characterized as neurogenic obesity due to an obligatory sarcopenia, neurogenic osteoporosis, neurogenic anabolic deficiency, sympatheti...
KEY FINDING: Individuals with SCI have altered energy balance due to sarcopenia, neurogenic osteoporosis, neurogenic anabolic deficiency, sympathetic dysfunction, and blunted satiety.
PLoS ONE, 2020 • July 29, 2020
The major finding of this study was that applying SCI specific WC cutoff point (> 86.5 cm) improves the diagnostic ability of the existing indices and criteria to accurately capture those at risk of d...
KEY FINDING: Using SCI specific WC cutoff point of 86.5 cm, 36% of participants were classified as obese compared to only 3% when using WC of 102 cm.
Journal of Personalized Medicine, 2020 • October 21, 2020
This study used a proteomic approach to identify biomarkers in blood plasma that could predict the response of patients with incomplete chronic traumatic spinal cord injury (SCI) to growth hormone (GH...
KEY FINDING: The combined treatment of GH plus rehabilitation is feasible and safe, and that GH but not placebo slightly improves the SCI individual motor score.
Top Spinal Cord Inj Rehabil, 2020 • July 1, 2020
Individuals with chronic spinal cord injury (SCI) are predisposed to accelerated atherogenesis, dyslipidemia, and glycemic dysregulation, although not enough is known about the etiologies or clinical ...
KEY FINDING: People with chronic SCI are at increased risk for atherogenesis and ischemic heart disease.
Frontiers in Physiology, 2021 • February 3, 2021
This study investigated the impact of paraplegia on dietary fat absorption by tracking the time course of exogenous fatty acid incorporation into the plasma triacylglycerol (TAG) pool in the postprand...
KEY FINDING: The study found no significant main effect of group (PARA vs. CON) on exogenous TAG, suggesting that the overall amount of fat absorbed wasn't significantly different.
Top Spinal Cord Inj Rehabil, 2021 • January 1, 2021
The study compares body composition assessment techniques in individuals with SCI to the 4-compartment (4C) model, the criterion standard for measuring body fat. A regression equation incorporating ag...
KEY FINDING: A regression equation using age, sex, weight, and abdominal skinfold thickness can estimate body fat with reasonable accuracy in SCI patients.
Top Spinal Cord Inj Rehabil, 2021 • January 1, 2021
This review examines insulin resistance and T2DM after SCI, noting the high prevalence of these conditions in the SCI population and the potential inadequacy of current assessment methods. The standar...
KEY FINDING: Individuals with SCI are at a higher risk of developing insulin resistance and type 2 diabetes mellitus (T2DM) compared to those without SCI.