Neural Regeneration Research, 2017 · DOI: 10.4103/1673-5374.217348 · Published: October 1, 2017
This study explores a new way to help rats recover from spinal cord injuries. It uses tiny particles to deliver a special substance (Nis-siRNA) that blocks a protein called nischarin. The scientists found that rats treated with these particles had better movement and less damage in their spinal cords. This suggests that blocking nischarin can help the spinal cord heal after an injury. The results showed that the nanoparticles carrying Nis-siRNA effectively suppressed nischarin expression, promoted the expression of growth-associated protein-43 (GAP-43), and accelerated motor function recovery after spinal cord injury in rats.
The study suggests a novel therapeutic approach for spinal cord injury using targeted gene silencing via nanoparticle delivery.
The use of PEI-ALG nanoparticles shows promise as an effective drug delivery system for siRNA in SCI treatment.
Further research is needed to elucidate the specific mechanisms by which nischarin suppression promotes axonal regeneration and to optimize the therapeutic application of PEI-ALG/Nis-siRNA nanoparticles.