Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 301-310 of 904 results
TISSUE ENGINEERING: Part A, 2021 • May 28, 2021
This study investigates the spatial relationships between regenerating axons and blood vessels within hydrogel scaffolds implanted into spinal cord injuries in rats. The findings revealed that Schwann...
KEY FINDING: Scaffolds containing Schwann cells (SCs) significantly enhanced axonal regeneration and blood vessel formation compared to Matrigel-only (MG) or SCs with rapamycin (RAPA).
Bioactive Materials, 2021 • March 9, 2021
The study demonstrates that cyclic mechanical loading can modulate the immunoinflammatory microenvironment and stimulate osteogenic differentiation of MSCs seeded on 3D scaffolds. ECM-based scaffolds ...
KEY FINDING: Mechanical loading downregulated inflammatory mediators (IL1B and IL8) and upregulated osteogenic markers (ALP and COL1A1) in MSCs seeded on scaffolds.
NEURAL REGENERATION RESEARCH, 2021 • November 1, 2021
This study investigates the use of a decellularized optic nerve (DON) scaffold seeded with neurotrophin-3 (NT-3)-overexpressing Schwann cells (SCs) to promote directional axon regeneration and remyeli...
KEY FINDING: Porcine decellularized optic nerve (DON) scaffolds exhibit uniformly distributed straight channels and microscopic pores, conducive to neural stem cell adhesion, survival, and migration.
Neural Regen Res, 2021 • March 25, 2021
This study introduces a novel porous collagen scaffold with axially-aligned luminal conduits as a nerve regenerative material for SCI repair. The scaffold, loaded with NSCs, markedly improved locomoto...
KEY FINDING: The collagen scaffold enhances neural stem cell activity and promotes cell extension without affecting cell differentiation in vitro.
Biomaterials, 2014 • September 1, 2014
The study investigates the distinct roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted intracortical microelectrodes using a bone marrow chimera m...
KEY FINDING: There was no correlation between microglia populations and neuron populations at the microelectrode-tissue interface.
Journal of NeuroEngineering and Rehabilitation, 2014 • July 3, 2014
This study introduces Motolink, an electronic spinal bridge that uses cortical signals to directly stimulate lower motor neurons after spinal cord injury in guinea pigs. The system records brain activ...
KEY FINDING: The researchers identified correlated activities of primary motor cortex neurons during treadmill walking of guinea pigs with spinal cord transection.
Frontiers in Neuroengineering, 2014 • August 27, 2014
This study analyzes the differences in movement-related cortical potential (MRCP) morphology during motor imagery between healthy volunteers (HV) and spinal cord injury (SCI) patients. The research ca...
KEY FINDING: The most notable abnormality observed was the amplified execution negativity and its slower rebound in the patient group compared to healthy volunteers.
Frontiers in Neuroscience, 2014 • September 2, 2014
This study presents a feedback-controlled arm neuroprosthesis for individuals with limited arm and shoulder function, combining NMES with a passive exoskeleton for gravity compensation. The system use...
KEY FINDING: The control system was able to perform a drinking task in all five healthy subjects, who remained passive during the movements.
Journal of NeuroEngineering and Rehabilitation, 2017 • September 7, 2017
This study introduces a novel multidimensional gait analysis method to assess the ability of body weight supported treadmill training (BWSTT) to improve rodent stepping after spinal cord injury (SCI)....
KEY FINDING: Stepping is asymmetrically altered 1 week after SCI. The differences in stepping change over the following weeks, with the less impaired left hindlimb deviating further away from pre-injury than the more impaired right hindlimb.
Acta Biomater., 2015 • January 1, 2015
The study assessed the biocompatibility of a coacervate-based drug delivery system in damaged nervous tissue using a rat model of contusive SCI, focusing on the effects of heparin and PEAD on inflamma...
KEY FINDING: The [PEAD:heparin] coacervate did not exacerbate inflammation, glial scarring, or nervous tissue loss, which are hallmarks of spinal cord injury.