Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 21-30 of 904 results
Scientific Reports, 2015 • January 19, 2015
This study established a high-throughput platform to investigate astrocyte-substrate interactions, revealing that astrocytes align along microgrooves with elongated and deformed nuclei. The research i...
KEY FINDING: Astrocytes on micropatterned surfaces exhibit changes in cell and nuclear elongation and alignment compared to flat surfaces.
PLoS ONE, 2012 • December 12, 2012
The study evaluated how surface structures support neurite outgrowth to push distance limits that can be bridged in nerve regeneration, using time-lapse video to monitor growth cone displacement of fl...
KEY FINDING: Surface structure variability enhanced net velocity by guiding growth cone movement.
Biomaterials, 2013 • March 1, 2013
This study investigates the impact of channel density and porosity in PLG bridges on neurite extension in rat and mouse spinal cord injury models. The findings demonstrate that bridges with higher por...
KEY FINDING: Increasing bridge porosity substantially increased the number of axons, correlating with the extent of cell infiltration throughout the bridge.
Adv Funct Mater, 2010 • May 10, 2010
This study developed nanofibrous scaffolds with aligned nanofibers for nerve guidance and drug delivery in spinal cord. The scaffolds with rolipram increased axon growth through the scaffolds and in t...
KEY FINDING: Scaffolds with rolipram significantly improved hindlimb function after 3 weeks in rats with spinal cord injury.
Biomatter, 2011 • October 1, 2011
Chondroitin sulfate is a major component of the extracellular matrix in both the central and peripheral nervous systems. Interestingly, the novel chondroitin sulfate-binding peptide enhances the contr...
KEY FINDING: PEG gels that contained only C6S (PEG-C6S) had the fastest NGF release, while gels that contained both BP and C6S had the slowest release profile (PEG-BP-C6S).
Int. J. Mol. Sci., 2013 • May 24, 2013
The study explores using magnetized olfactory ensheathing cells (OECs) for treating spinal cord injuries. OECs are modified with magnetic nanoparticles (MNPs) to enable controlled migration via magnet...
KEY FINDING: Magnetized OECs survive well without showing stress-related cellular responses.
J Control Release, 2013 • September 28, 2013
The study investigates the use of polysaccharide-modified PLG scaffolds for controlled lentivirus delivery to enhance tissue regeneration, particularly in spinal cord injuries. Surface modification wi...
KEY FINDING: Chitosan and heparin modification of PLG scaffolds significantly enhanced lentivirus association and transduction efficiency in vitro compared to hyaluronan and control scaffolds.
The Journal of Spinal Cord Medicine, 2013 • May 1, 2013
This systematic review analyzes studies using biomaterials to promote neuronal regeneration after spinal cord injury (SCI) in rodents. The review focuses on multimodal interventions combining biodegra...
KEY FINDING: Biomaterial-based interventions resulted in modest functional improvement in rodent models of SCI.
International Journal of Nanomedicine, 2013 • June 20, 2013
The study investigates the therapeutic potential of iron oxide nanoparticles (IONPs) and magnetic field (MF) exposure in rats with complete spinal cord injury (SCI). Locomotor and sensorimotor assessm...
KEY FINDING: IONP implantation combined with MF exposure significantly reduced functional deficits after spinal cord injury in rats.
Neurosci Bull, 2013 • August 1, 2013
Spinal cord injury (SCI) results in permanent loss of function. A contributing factor to the permanence of SCI is that damaged axons do not regenerate, which prevents the re-establishment of axonal ci...
KEY FINDING: Axonal regeneration is considered an important repair mechanism for the injured spinal cord and materials that have shown most promise to elicit an axonal regeneration response to foster functional restoration after SCI are reviewed.