Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 11-20 of 904 results
Biomaterials, 2012 • February 1, 2012
The study investigates the delivery of lentiviral vectors from multiple channel bridges as a combinatorial approach to promote regeneration in the injured spinal cord. Lentivirus induced expression of...
KEY FINDING: Lentivirus-loaded bridges resulted in localized protein expression within the injury site, with lower expression in adjacent tissue, with expression maximal at the implantation site.
Exp Neurol, 2012 • May 1, 2012
This study investigated the potential of salmon fibrin as an injectable scaffold for treating spinal cord injury in rats. The researchers compared the effects of salmon fibrin, human fibrin, and no tr...
KEY FINDING: Rats treated with salmon fibrin exhibited significantly improved recovery of both locomotor and bladder function compared to those treated with human fibrin or left untreated.
TISSUE ENGINEERING: Part A, 2012 • February 7, 2012
The study investigates the potential of electrospun collagen nanofibers for spinal cord injury (SCI) treatment, addressing the limitations of current methods due to the inhibitory microenvironment afte...
KEY FINDING: Astrocytes cultured on collagen nanofibers showed suppressed proliferation and GFAP expression compared to those on 2D controls.
Neurosci Lett, 2012 • June 25, 2012
The review summarizes recent attempts to engineer the CNS extracellular environment after injury using combinatorial strategies involving neurotrophin delivery, cell transplantation, and biomaterial s...
KEY FINDING: Combining neurotrophic factor delivery with cell transplantation or biomaterial scaffolds may provide synergistic effects to improve functional recovery after spinal cord injury.
J. Vis. Exp., 2012 • February 16, 2012
The spinal cordslice is an ideal recipient tissue for studying NPC ex vivo behaviours, post-transplantation, because the cytoarchitectonic tissue organization is well preserved within these cultures T...
KEY FINDING: NPCs showed highly directed cell migration towards the cathode when exposed to a range of physiological EFs.
Cell Tissue Res, 2012 • March 14, 2012
Important advances in the development of smart biodegradable implants for axonal regeneration after spinal cord injury have recently been reported. These advances are evaluated in this review with spe...
KEY FINDING: The corticospinal tract is often considered the ultimate challenge in demonstrating the success of repair strategies for spinal cord regeneration.
International Journal of Nanomedicine, 2012 • April 13, 2012
The study combines PLGA conduits and neurotrophin-3 (NT-3) to generate NT-3-loaded PLGA carriers in vitro, showing stable NT-3 release for up to 4 weeks. Coseeding NSCs and SCs into NT-3-releasing sca...
KEY FINDING: NT-3-loaded PLGA carriers stably release bioactive NT-3 for up to 4 weeks.
Journal of Visualized Experiments, 2012 • August 9, 2012
The study focuses on evaluating biomaterials for bladder augmentation using cystometric analyses in rodent models. Surgical implantation of gastrointestinal segments, the primary treatment for bladder...
KEY FINDING: Variations in structural and mechanical implant properties can influence the urodynamic features of tissue-engineered bladders.
Biomaterials, 2012 • November 1, 2012
The study details the fabrication of gelatin tubes and membranes for spinal cord repair, focusing on improving mechanical properties and biocompatibility. In vitro studies showed that the gelatin memb...
KEY FINDING: Gelatin membranes with rhBDNF improved Schwann cell adhesion, alignment, and proliferation.
Biomaterials, 2013 • February 1, 2013
This study assessed the potential of bioengineered scaffolds to support and guide axonal growth in a severe spinal cord injury model involving complete spinal cord transection in adult rats. The findi...
KEY FINDING: Templated agarose scaffolds support motor axon regeneration into a severe spinal cord injury model.