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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Biomedical Research

Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.

Showing 161-170 of 904 results

Regenerative MedicineNeurologyBiomedical

Regenerative Therapies for Central Nervous System Diseases: a Biomaterials Approach

Neuropsychopharmacology Reviews, 2014 • January 1, 2014

The central nervous system's limited regenerative capacity necessitates innovative strategies for tissue and functional repair. Biomaterials, particularly hydrogels, are being investigated as cell- an...

KEY FINDING: Biomaterial hydrogels can enhance cell survival and integration in the CNS by mimicking the extracellular matrix (ECM) and providing physical support.

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PharmacologyNeurologyBiomedical

Click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries

Acta Pharmaceutica Sinica B, 2023 • May 1, 2023

This study introduces a novel approach for treating CNS injuries, particularly stroke, by utilizing engineered extracellular vesicles (EVs) derived from M2 microglia. The EVs are modified with DA7R an...

KEY FINDING: Dual-EV nanocarriers target human umbilical vascular endothelial cells (HUVECs) and recruit NSCs in vitro.

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Regenerative MedicineNeurologyBiomedical

Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury

Nature Communications, 2023 • July 12, 2023

This study introduces an advanced MN-MSC patch that enables sustained delivery of MSC-EVs to the injured spinal cord, avoiding direct stem cell invasion. The MN patch, made of biocompatible porous Gel...

KEY FINDING: The porous MN-MSC patch can effectively maintain the survival of MSCs and sustainably release MSC secretome for at least one week.

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Spinal Cord InjuryRegenerative MedicineBiomedical

Improving motor neuron‑like cell differentiation of hEnSCs by the combination of epothilone B loaded PCL microspheres in optimized 3D collagen hydrogel

Scientific Reports, 2021 • November 4, 2021

The study aimed to enhance the differentiation potential of hEnSCs into MN-like cells and axonal elongation using the signaling molecules sonic hedgehog (SHH) and retinoic acid (RA), and also by provi...

KEY FINDING: The collagen hydrogel containing EpoB microspheres significantly improved the differentiation of hEnSCs into motor neuron-like cells.

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Assistive TechnologyNeurologyBiomedical

ICEP: An Instrumented Cycling Ergometer Platform for the Assessment of Advanced FES Strategies

Sensors, 2023 • March 28, 2023

This study presents a new instrumented cycling ergometer platform (ICEP) designed for assessing functional electrical stimulation (FES) strategies in individuals with spinal cord injuries (SCI). The p...

KEY FINDING: The stimulation pattern derived from the SCI subject’s force output produced 14% more power than the EMG-derived stimulation pattern.

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Assistive TechnologyRehabilitationBiomedical

Hybrid brain/neural interface and autonomous vision‑guided whole‑arm exoskeleton control to perform activities of daily living (ADLs)

Journal of NeuroEngineering and Rehabilitation, 2023 • May 8, 2023

This study compares the control of a whole-arm exoskeleton and an external manipulator using a hybrid EEG/EOG interface in individuals with brain or spinal cord injuries. The study suggests that the e...

KEY FINDING: The study found no significant differences in the time spent to fully open/close the hand exoskeleton and the gripper of the robotic external manipulator through the EEG interface normalized to ERD duration.

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Assistive TechnologyBiomedicalBiomechanics

Reducing the muscle activity of walking using a portable hip exoskeleton based on human-in-the-loop optimization

Front. Bioeng. Biotechnol., 2023 • May 4, 2023

This study introduces a muscle-activity-based human-in-the-loop (HIL) optimization strategy for a portable hip exoskeleton to reduce the time spent on collecting biosignals during each iteration. The ...

KEY FINDING: Human-in-the-loop optimization led to muscle activity reduction of 33.56% and 41.81% at most when compared to walking without and with the hip exoskeleton, respectively.

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Spinal Cord InjuryNeurologyBiomedical

Identifying Intraoperative Spinal Cord Injury Location from Somatosensory Evoked Potentials’ Time-Frequency Components

Bioengineering, 2023 • June 11, 2023

This study investigates the potential of using somatosensory evoked potentials (SEPs) and their time-frequency components to identify the location of spinal cord injuries (SCI) during corrective spine...

KEY FINDING: There was a significant delay in the latency of the time-frequency components distributed between 15 and 30 ms and 50 and 150 Hz in all spinal cord injury groups.

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Spinal Cord InjuryNeurologyBiomedical

Correction: Neuromodulation for recovery of trunk and sitting functions following spinal cord injury: a comprehensive review of the literature

Bioelectronic Medicine, 2023 • January 1, 2023

This is a correction to a previously published article. The correction addresses errors found in figures 3 and 4 of the original article. The corrected figures are provided in this article.

KEY FINDING: Errors were identified in Figure 3 of the original article.

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Assistive TechnologyRehabilitationBiomedical

Development of a Control Strategy in an Isokinetic Device for Physical Rehabilitation

Sensors, 2023 • June 22, 2023

This paper presents the development of a control system for an isokinetic rehabilitation device, focusing on the recovery of leg muscle injuries. The system employs a magnetic particle brake for speed...

KEY FINDING: Viewing the knee joint as simplified geometric figures facilitates understanding ligament and muscle interactions during leg flexion and extension.

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