Bioinformatics Research

KEY FINDING: Microglia participate in neuroinflammation and play a significant role in the clearance mechanism of apoptotic cells following SCI.

KEY FINDING: Age, preoperative mJOA scale, and symptom duration were independent predictors of poor clinical outcome.

KEY FINDING: The accuracy of age prediction was higher when no site harmonization (correction for differences between data collection sites) was applied to the brain imaging data.

KEY FINDING: The study identified 890 differentially expressed genes (DEGs) in GBM cells, with 475 upregulated and 415 downregulated.

KEY FINDING: scPrivacy effectively integrates information from multiple datasets while preserving data privacy, addressing a key challenge in single-cell data analysis.

KEY FINDING: The GAG-Dock method accurately reproduces the binding poses of heparin to proteins, as validated against known crystal structures.

KEY FINDING: Schwann cells migrate towards the anode in an applied electric field, and the directedness and displacement of migration increase with the strength of the electric field.

KEY FINDING: AI algorithms, including random forests, deep neural networks, and convolutional neural networks, have been used to predict motor outcomes after stroke with AUCs ranging from 0.7 to 0.9.

KEY FINDING: Electroacupuncture (EA) significantly increased the mechanical pain threshold in rats with diabetic painful neuropathy (DPN).

KEY FINDING: White individuals had higher levels of ALT, BUN, BUN/Creatinine ratio, sodium, and chloride in their blood.