Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 291-300 of 334 results
Scientific Reports, 2015 • November 10, 2015
The study aimed to characterize the large genome of the Mexican axolotl salamander (Ambystoma mexicanum) using shotgun and laser capture chromosome sequencing. Researchers generated 600 Gb of shotgun ...
KEY FINDING: The A. mexicanum genome is estimated to be ~32 Gb.
BMC Developmental Biology, 2015 • November 16, 2015
The study characterized histological and transcriptional differences between EB and apical-LB tissue compared to basal-LB tissue. The stability of positional information is associated with tissue orga...
KEY FINDING: Basal-LB samples showed greater tissue organization than EB and apical-LB samples.
PLoS ONE, 2016 • January 25, 2016
This study utilizes a systems biology approach to identify novel drug combinations for the treatment of ALS. The researchers screened existing compounds and identified Alitretinoin plus Pranlukast (CD...
KEY FINDING: The drug combinations Alitretinoin plus Pranlukast (CD1) and Alitretinoin plus Mefloquine (CD2) were identified as potentially useful to treat ALS.
Neural Regeneration Research, 2016 • March 1, 2016
This study investigates dynamic mRNA expression patterns in rats following spinal cord ischemia/reperfusion injury using DNA microarrays. The study identified five significant mRNA dynamic expression ...
KEY FINDING: 8,242 differentially expressed mRNAs were obtained by Multi-Class Dif in the simple ischemia group, 24-hour and 48-hour reperfusion groups.
Molecular & Cellular Proteomics, 2016 • June 1, 2016
This study provides an exhaustive spatio-temporal proteomic and biochemical analysis performed along the entire spinal cord axis in a rat model of SCI. The researchers identified specific markers for ...
KEY FINDING: Molecular and cellular processes after SCI differ significantly between segments near the lesion (R1-C1) and those further away (R2-C2 and R3-C3).
Computational and Mathematical Methods in Medicine, 2016 • March 28, 2016
This study presents a mathematical model to investigate axon regeneration around glial scars after spinal cord injury, focusing on the impact of inhibitory factors and scar size. The model, based on S...
KEY FINDING: The level of inhibitory factors on the surface of glial scar significantly impacts axon elongation.
Journal of Orthopaedic Surgery and Research, 2016 • September 5, 2016
This study aimed to identify key molecular pathways involved in spinal cord injury (SCI) by analyzing gene expression profiles in rats at different time points after injury. The analysis revealed 416 ...
KEY FINDING: A total of 416 genes showed significant differential expression at all time points after SCI, suggesting their consistent involvement in the injury response.
eLife, 2016 • November 25, 2016
This study investigates the cellular mechanisms underlying spinal cord regeneration in axolotls, focusing on cell proliferation, neural stem cell activation, and cell influx. The researchers identifie...
KEY FINDING: The regenerating spinal cord grows with increasing velocity during the first 8 days.
Cell Rep, 2017 • March 14, 2017
The study identifies LPPR1 and LPAR1 as intrinsic axon growth modulators for intact corticospinal motor neurons after spinal cord injury. In vivo inhibition of LPAR1 or overexpression of LPPR1 enhance...
KEY FINDING: LPPR1 and LPAR1 were identified as intrinsic axon growth modulators for intact corticospinal motor neurons after adjacent injury.
Molecular & Cellular Proteomics, 2017 • June 28, 2017
This study explores the therapeutic potential of RhoA inhibitors (RhoAi) in treating spinal cord injury (SCI) by investigating their effects on neurite outgrowth and synaptogenesis both in vitro and i...
KEY FINDING: RhoAi treatment stimulates neurite outgrowth in both in vitro and in vivo environments, suggesting its potential to promote nerve regeneration after SCI.