Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 4,081-4,090 of 12,052 results
BMC Neuroscience, 2022 • September 1, 2022
This study investigated the impact of morphine on immune cells (microglia and macrophages) following spinal cord injury (SCI) in rats. The research aimed to understand how morphine affects the inflamm...
KEY FINDING: Morphine significantly increased the number of microglia and macrophages around the spinal cord lesion after SCI.
Ann Transl Med, 2022 • September 1, 2022
This retrospective study analyzed 48 patients with Kümmell disease, classifying them into six types based on clinical and imaging findings. Different surgical approaches were used for each type, inclu...
KEY FINDING: The study found that visual analog scale (VAS) and Owestry disability index (ODI) scores improved significantly in all patients after surgery.
Ann Transl Med, 2022 • September 1, 2022
This study used iTRAQ proteomics to analyze the proteome profiles of BMSCs cocultured with SCs, identifying 243 differentially expressed proteins (DEPs). Bioinformatics analyses (GO and KEGG) indicate...
KEY FINDING: A total of 6,760 types of proteins were detected, with 5,181 having quantitative information. Among these, 243 DEPs were identified.
Basic and Clinical Neuroscience, 2022 • September 1, 2022
The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating ChABC in improving the complicatio...
KEY FINDING: ChABC administration improves locomotion recovery after SCI.
Global Spine Journal, 2022 • September 1, 2022
This retrospective study evaluated the functional outcomes and characteristics associated with gunshot wounds (GSW) to the spine, analyzing data from 51 patients treated at a Level 1 Trauma Center bet...
KEY FINDING: Most patients with spinal GSW did not experience clinical improvement in their ambulatory status, with the majority having severe injuries (ASIA A).
J Head Trauma Rehabil, 2022 • September 1, 2022
This study examined the relationship between TBI-related hearing impairment and cognitive function in a large cohort of patients from Level I trauma centers. The results indicated a small but signific...
KEY FINDING: TBI-related hearing impairment was significantly associated with worse executive functioning, as measured by the Trail Making Test (TMT) B/A ratio.
Neural Regeneration Research, 2022 • September 1, 2022
CSPGs inhibit axon regeneration after SCI by interacting with receptors like PTPσ, LAR, and NgRs, activating RhoA and inactivating Akt signaling pathways. ChABC treatment can remove CSPGs, reactivate ...
KEY FINDING: Digestion of CSPGs with ChABC reduces retrograde apoptotic signaling and enhances true axon regeneration in lampreys after spinal cord transection.
Int Wound J, 2022 • September 1, 2022
This proof-of-concept study examined objective skin blood flow measurement as a bedside approach to quantify microvascular function during acute hospitalisation of traumatic SCI. The study compared di...
KEY FINDING: Objective and non-invasive skin blood flow measurements can be obtained at the bedside during acute hospitalization of spinal cord injury (SCI) for research purposes.
Am J Psychiatry, 2022 • September 1, 2022
This study investigated the predictive capacity of persistent derealization, a type of dissociation, for adverse psychiatric outcomes following acute trauma. The research found that derealization, mea...
KEY FINDING: Derealization was associated with increased activity in the ventromedial prefrontal cortex (vmPFC) during an emotion reactivity task.
J Biomech, 2022 • September 1, 2022
The study examined the biomechanics of geared manual wheelchair propulsion in individuals with SCI across various terrains. Results indicated that low gear reduces propulsion speed, peak hand-rim forc...
KEY FINDING: Using low gear decreased propulsion speed compared to standard gear.