Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,851-3,860 of 12,052 results
Cells, 2022 • October 20, 2022
Neural precursor cell (NPC) transplantation represents a promising therapy for treating spinal cord injuries (SCIs); however, despite successful results obtained in preclinical models, the clinical tr...
KEY FINDING: In vitro, expanded hfNPCs retained neural features, multipotency, and self-renewal, which supported the development of a cell banking strategy.
Frontiers in Cardiovascular Medicine, 2022 • October 20, 2022
This meta-analysis compares the outcomes of conventional elephant trunk (ET) and frozen elephant trunk (FET) techniques for aortic arch surgery, focusing on early mortality and major complications. Th...
KEY FINDING: ET is associated with higher early mortality compared to FET (RR 1.37 [1.04 to 1.81], p = 0.027) when considering all studies published between 2008 and 2021.
Frontiers in Cellular Neuroscience, 2022 • October 20, 2022
This study found that microglial activation mediated NLRP3-related neuroinflammation in the motor cortex after SCI, which resulted in the injury to motor neurons, affected the integrity of motor pathw...
KEY FINDING: Microglial activation in the motor cortex (M1) mediates NLRP3-related neuroinflammation following SCI.
Heliyon, 2022 • October 20, 2022
The study investigates the effect of Erxian Decoction (EXD) on spinal cord injury (SCI) repair in rats, focusing on the underlying molecular mechanisms. The research demonstrates that EXD significantl...
KEY FINDING: EXD improved motor function at 7 days post-injury (dpi) in SCI rats.
Journal of Clinical Orthopaedics and Trauma, 2022 • October 20, 2022
This review demonstrates ML contributions toward 1) diagnostic accuracy with advances in MRI segmentation and classification 2) acute blood pressure management for optimizing functional AISIA classifi...
KEY FINDING: Machine learning shows promise in improving diagnostic accuracy through advances in MRI segmentation and classification.
Frontiers in Pharmacology, 2022 • October 19, 2022
Muse cells are endogenous pluripotent-like stem cells found in various tissues, exhibiting triploblastic differentiation, self-renewal, stress tolerance, and reparative function. They home to damaged ...
KEY FINDING: Muse cells selectively accumulate at damaged sites by sensing sphingosine-1-phosphate (S1P), a key mediator of inflammation.
Frontiers in Pharmacology, 2022 • October 19, 2022
Neurological diseases pose a significant burden, and their complex pathogenesis necessitates multi-targeted treatments. Traditional Chinese medicine, particularly TWHF extracts like triptolide and cel...
KEY FINDING: Triptolide and celastrol exhibit therapeutic effects in Alzheimer's disease by inhibiting Aβ deposition, reducing neuroinflammation, decreasing ROS levels, attenuating apoptosis, enhancing autophagy, and exerting neurotrophic effects.
Neural Plasticity, 2022 • October 19, 2022
This study investigated the effect of exercise on neuropathic pain in mice with spared nerve injury (SNI). The researchers examined pain behavior and molecular changes in the spinal cord. The study fo...
KEY FINDING: Spared nerve injury (SNI) led to mechanical and cold allodynia, elevated expression of latency-associated peptide- (LAP-) TGF-β1, and activated astroglial in the spinal cord.
Frontiers in Aging Neuroscience, 2022 • October 19, 2022
The authors found that the NLRP3 inflammasome plays an important role in the treatment of some diseases by electroacupuncture. The main mechanism is that electroacupuncture reduces the inflammatory resp...
KEY FINDING: Electroacupuncture can alleviate diseases by targeting the NLRP3 inflammasome.
Computational and Structural Biotechnology Journal, 2022 • October 18, 2022
This study investigates the regenerative capacity of descending CRH axons in larval sea lampreys after complete spinal cord injury (SCI). The results demonstrate a full regeneration of CRH-immunoreact...
KEY FINDING: At 10 weeks post-lesion, injured lampreys recovered normal appearing locomotion.