Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,831-3,840 of 12,052 results
Cells, 2022 • October 28, 2022
This systematic review and meta-analysis aimed to identify promising experimental treatments for spinal cord injury (SCI) that promote neuroregeneration and neuroprotection. The review analyzed 44 stu...
KEY FINDING: The combined use of tetrahedral framework nucleic acid (tFNA) with neural stem cells (NSCs) significantly improved functional recovery in SCI models, as measured by the BBB locomotion test.
Biomedicines, 2022 • October 28, 2022
This study investigates a novel approach combining magnetic and electric stimulation to enhance NPC proliferation and differentiation on PLA scaffolds. The research compares continuous and intermitten...
KEY FINDING: Continuous stimulation promotes NPC proliferation significantly more than intermittent stimulation and the control group.
International Journal of Environmental Research and Public Health, 2022 • October 28, 2022
This study compared health service usage and distances travelled by people with transport-related orthopaedic, brain and spinal cord injuries across regional and metropolitan Victoria in the first thre...
KEY FINDING: People with orthopaedic injuries and TBI in regional areas had greater odds of seeing a GP compared with their metropolitan counterparts.
Malays J Med Sci, 2022 • October 28, 2022
This study investigated the cut-off point for knee extensor muscle strength to independently determine the ability of patients with iSCI to stand up five times from a chair without using their hands f...
KEY FINDING: Knee extensor muscle strength ≥ 53.06 Newton was the best independent predictor of the FTSST results, with a sensitivity of 72.7% and specificity of 72.7%.
Int. J. Mol. Sci., 2022 • October 27, 2022
Stem cell therapy is a promising treatment for SCI due to its multiple targets and reactivity benefits. Various stem cell lines can be used, each associated with specific advantages and disadvantages. I...
KEY FINDING: NSC from E14 mice on multichannel PLG scaffold increases density of axons and myelin regeneration and leads to a more rapid and functional recovery
Biomedicines, 2022 • October 27, 2022
This study investigates the effects of exogenous FGF-1 on oligodendrocyte replenishment in a spinal cord injury (SCI) model and cultured cells. The research focuses on understanding how FGF-1 influenc...
KEY FINDING: FGF-1 treatment resulted in a reduction in the number of NG2+OX42−OPCs at the injury site, indicating a decrease in the accumulation of oligodendrocyte progenitor cells.
International Journal of Molecular Sciences, 2022 • October 27, 2022
The study demonstrates that non-invasive modulation of neuronal activity in the spinal cord, using bioluminescent optogenetics with a new, more light-sensitive luminopsin (LMO3.2), significantly impro...
KEY FINDING: LMO3.2 induces higher photocurrents compared to LMO3, indicating a greater response to both blue light and CTZ-induced activation.
Neurochemical Research, 2022 • October 26, 2022
The study aimed to investigate the effects of linalyl acetate (LA) on neuropathic pain caused by sciatic nerve injury (SNI) in rats, focusing on the TSLP and IL-33 signaling pathways. The results show...
KEY FINDING: LA attenuated mechanical hyperalgesia in SNI rats, indicating a reduction in pain sensitivity.
Frontiers in Rehabilitation Sciences, 2022 • October 26, 2022
This study measured the gut microbiome in the first three weeks of rehabilitation following stroke and its associations with leaky gut markers, dietary intake, and functional recovery measures. The re...
KEY FINDING: Stroke patients had significantly lower abundances of butyrate producers, secondary bile acid producers, equol producers, and sulfate reducers in their gut.
Contemporary Clinical Trials Communications, 2022 • October 26, 2022
This study protocol outlines a randomized controlled trial to assess the efficacy of Brief Prolonged Exposure (PE) therapy in preventing posttraumatic stress disorder (PTSD) among individuals with spi...
KEY FINDING: The primary outcome measure is PTSD symptoms measured by the PSSI-5 at baseline, 1-month, 3-months, and 6-months.