Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,861-11,870 of 12,052 results
Cellular and Molecular Life Sciences, 2008 • November 3, 2007
Investigations into mechanisms that restrict the recovery of functions after an injury to the brain or the spinal cord have led to the discovery of specific neurite growth inhibitory factors in the ad...
KEY FINDING: Neutralizing Nogo-A promotes axonal regeneration of various types of CNS neurons.
The Journal of Neuroscience, 2007 • October 31, 2007
This symposium summarizes scientific bases for current clinical trials aimed at improving functions after SCI. After primary and secondary damage, endogenous processes may foster or hinder axonal reco...
KEY FINDING: Function-blocking antibodies recognizing Nogo-A induce enhanced regenerative sprouting from injured fibers, long-distance regeneration of subpopulations of fibers, and enhanced compensatory fiber growth from non-injured fibers and tracts.
TheScientificWorldJOURNAL, 2007 • October 22, 2007
The study compared intravesical oxybutynin, propantheline, and capsaicin for treating neurogenic detrusor overactivity (NDO) following spinal cord injury (SCI). Capsaicin showed statistically signific...
KEY FINDING: Intravesical capsaicin significantly improved reflex volume, cystometric capacity, leak volume, and leak frequency in treating neurogenic detrusor overactivity.
Exp Neurol, 2007 • October 1, 2007
This study investigates the therapeutic potential of utilizing neurotrophin-transduced Schwann cells (SCs) to repair the injured spinal cord in a rat model of contusion. Schwann cells were transduced ...
KEY FINDING: D15A-secreting SC grafts exhibited 5-fold increases in graft volume, SC number and myelinated axon counts and a 3-fold increase in myelinated to unmyelinated (ensheathed) axon ratios.
BMC Neuroscience, 2007 • September 27, 2007
The study investigated axonal regeneration in NG2 knockout mice compared to wild-type controls after injuries to the CNS (corticospinal tract, dorsal column, dorsal root) and PNS (sciatic and facial n...
KEY FINDING: NG2 deficiency did not enhance regeneration of corticospinal tract axons after spinal cord injury.
The Journal of Neuroscience, 2007 • September 26, 2007
This study investigated whether transient delivery of growth factors could sustain regenerated axons after spinal cord injury (SCI). The researchers used a tetracycline-inducible system to control BDN...
KEY FINDING: Transient growth factor delivery is sufficient to sustain long-term axonal projections into a site of SCI.
Purinergic Signalling, 2007 • September 25, 2007
This study investigates the potential neuroprotective effects of guanosine in rats with acute spinal cord injury. The researchers hypothesized that guanosine could mitigate secondary injury mechanisms...
KEY FINDING: Guanosine treatment significantly improved motor and sensory functions in rats with spinal cord injury, as measured by open field walking, hind limb placing, foot orienting, inclined plane, and hot plate tests.
Neuroscience, 2007 • September 21, 2007
This study demonstrates that the spinal cord can learn a sensorimotor task independently of the brain, and that this learning is associated with increased expression of BDNF and related molecules (CaM...
KEY FINDING: Instrumental learning in spinally transected rats increased mRNA levels of BDNF, CaMKII, CREB, and synapsin I in the lumbar spinal cord.
Eur Spine J, 2007 • September 21, 2007
The study aimed to evaluate the efficacy of adenovirus vector-mediated BDNF ex vivo gene transfer to BMSC in adult rats with completely transected spinal cords. The results showed that BMSC transplant...
KEY FINDING: Adenovirus vector-mediated ex vivo gene transfer of BDNF to BMSC enhances axonal regeneration in completely transected spinal cord.
Cell Mol Neurobiol, 2007 • September 19, 2007
The study investigates changes in cAMP levels in the developing opossum spinal cord during the critical period when regeneration stops being possible. Endogenous cAMP levels were measured in tissue ho...
KEY FINDING: A significant decrease in cAMP levels was observed during the period when the opossum spinal cord loses its regenerative capability.