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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Latest Research Summaries

Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.

Showing 11,851-11,860 of 12,052 results

NeurologyGenetics

Topographic Specificity within Membranes of a Single Muscle Detected In Vitro

The Journal of Neuroscience, 2007 • December 19, 2007

This study investigates the mechanisms underlying neuromuscular maps by studying the preferential outgrowth of embryonic spinal cord neurites on muscle membranes from different axial positions and exp...

KEY FINDING: Rostral cervical spinal cord neurites prefer to grow on rostral diaphragm membranes, while caudal cervical neurites prefer caudal diaphragm membranes.

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Spinal Cord InjuryNeurology

Electrical Stimulation of Spared Corticospinal Axons Augments Connections with Ipsilateral Spinal Motor Circuits after Injury

The Journal of Neuroscience, 2007 • December 12, 2007

The study demonstrates that activity promotes plasticity in the mature corticospinal (CS) system and that the interplay between activity and injury preferentially promotes connections with ventral spi...

KEY FINDING: Both electrical stimulation and injury alone strengthened ipsilateral corticospinal (CS) connectivity.

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Regenerative MedicineNeurologyRehabilitation

Experimental Study of Low Dose Ultrashortwave Promoting Nerve Regeneration after Acellular Nerve Allografts Repairing the Sciatic Nerve Gap of Rats

Cell Mol Neurobiol, 2008 • December 6, 2007

The study aimed to observe the effect of ultrashortwave (USW) therapy on nerve regeneration after acellular nerve allografts (ANA) repairing the sciatic nerve gap of rats. USW therapy can promote nerv...

KEY FINDING: USW therapy can increase nerve conductive velocity compared to acellular nerve allografts alone.

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Spinal Cord InjuryRegenerative MedicinePhysiology

Structural differentiation of skeletal muscle fibers in the absence of innervation in humans

PNAS, 2007 • December 4, 2007

This study examined the impact of functional electrical stimulation (FES) on denervated muscles in spinal cord injury patients. The patients underwent FES for 2.4-9.3 years. Results showed significant...

KEY FINDING: FES treatment significantly increased muscle fiber diameter in denervated muscles compared to untreated muscles. The fiber size increase was accompanied by a reduction in connective and adipose tissues.

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Spinal Cord InjuryMental Health

Resilient, Undercontrolled, and Overcontrolled Personality Prototypes Among Persons With Spinal Cord Injury

J Pers Assess, 2007 • December 1, 2007

This study investigated personality prototypes among individuals with spinal cord injury (SCI) using the NEO Five-Factor Inventory. Three prototypes—resilient, undercontrolled, and overcontrolled—were...

KEY FINDING: The study found that individuals with SCI had fewer resilient personality types and more undercontrolled and overcontrolled types compared to the general population.

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Spinal Cord InjuryUrologyBiomedical

Intraspinal stimulation for bladder voiding in cats before and after chronic spinal cord injury

J Neural Eng, 2007 • December 1, 2007

This study evaluated the effects of intraspinal microstimulation on bladder voiding in cats before and after spinal cord injury. Microelectrode arrays were implanted in the sacral spinal cord to stimu...

KEY FINDING: Stimulation at the S1 level produced strong bladder contractions and EUS relaxation, resulting in voiding in 14 animals.

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NeurologyNeurorehabilitationRehabilitation

Upper limb impairments associated with spasticity in neurological disorders

Journal of NeuroEngineering and Rehabilitation, 2007 • November 29, 2007

The study characterized impairments in voluntary arm movement associated with spasticity in stroke and SCI subjects. Impairments in arm voluntary movement were similar in the two spastic groups, altho...

KEY FINDING: Most kinematic and kinetic parameters changed significantly in paretic as compared to normal arms in stroke subjects.

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Regenerative MedicineGenetics

Transforming Growth Factor: b Signaling Is Essential for Limb Regeneration in Axolotls

PLoS ONE, 2007 • November 28, 2007

This study investigates the role of TGF-b signaling in axolotl limb regeneration, highlighting the contrast with TGF-b's role in mammalian wound healing, which often results in scarring. The researche...

KEY FINDING: The full-length cDNA sequence of axolotl TGF-b1 was isolated, revealing high homology with mammalian TGF-b1 sequences.

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SurgeryOrthopedics

Limitation of activities of daily living accompanying reduced neck mobility after laminoplasty preserving or reattaching the semispinalis cervicis into axis

Eur Spine J, 2008 • November 24, 2007

This retrospective study compared the frequency of limitations of ADL accompanying neck mobility after laminoplasty preserving the semispinalis cervicis inserted into the C2 spinous process with that ...

KEY FINDING: The frequency of limitations of ADL accompanying extension was lower in Group A (2%) than in Group B (17%) (P = 0.037).

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Regenerative MedicineNeurologyGenetics

Successful neural regeneration in amniotes: the developing chick spinal cord

Cell. Mol. Life Sci., 2008 • November 20, 2007

Significant spinal cord regeneration following injury is not observed in any adult higher vertebrates (amniotes), but can occur in some lower vertebrates (anamniotes) such as tailed amphibians and fis...

KEY FINDING: Clearwaters reported regeneration in the embryonic spinal cord, but lack of regeneration and extensive scarring in the postnatal spinal cord.

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