The Effectiveness of Intravesical Oxybutynin, Propantheline, and Capsaicin in the Management of Neuropathic Bladder following Spinal Cord Injury

Neuropathic bladder after spinal cord injury can lead to urinary incontinence and kidney problems. This study explores using medications directly in the bladder to manage this issue. The study compares oxybutynin, propantheline, and capsaicin, delivered directly into the bladder, to see which is most effective in reducing bladder overactivity. The goal is to find a treatment that reduces the systemic side effects often caused by oral medications, while still improving bladder control.

• 1
  Intravesical capsaicin significantly improved reflex volume, cystometric capacity, leak volume, and leak frequency in treating neurogenic detrusor overactivity.
• 2
  Propantheline showed more improvement than oxybutynin for reflex volume, detrusor leak point pressure, clean intermittent catheterization volume, and leak volume.
• 3
  Significant differences were found in the therapeutic response between oxybutynin, propantheline, and capsaicin for leak volume and leak frequency at 2 weeks.