Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,821-11,830 of 12,052 results
J Hand Surg Am, 2008 • April 1, 2008
This study evaluated a second-generation implanted neuroprosthesis controlled by myoelectric signals to restore hand and arm function in individuals with C5/C6 spinal cord injuries. The results demons...
KEY FINDING: EMG signals can be recorded from voluntary muscles even during electrical stimulation of nearby muscles.
Exp Neurol, 2008 • April 1, 2008
The study examined whether manipulating a spinal cord contusion injury site prior to transplantation affects behavioral recovery and axonal regeneration. Aspiration of the injury site was performed at...
KEY FINDING: Manipulation of a contusion injury site prior to transplantation does not cause long-lasting forelimb or hindlimb behavioral deficits.
Nat Neurosci, 2008 • April 1, 2008
Systemic artemin treatment caused the regeneration of damaged axons, resulting in virtually complete and long-lasting restoration of nociceptive and sensorimotor functions. Artemin, given in six syste...
KEY FINDING: Systemic artemin administration promotes the regrowth of both myelinated and unmyelinated axons through the dorsal root entry zone (DREZ).
Neurosci Bull, 2008 • April 1, 2008
This study combined olfactory ensheathing glia (OEG) implantation with ex vivo non-viral vector-based neurotrophin-3 (NT-3) gene therapy to enhance regeneration after thoracic spinal cord injury (SCI)...
KEY FINDING: NT-3 production was seen increased both ex vivo and in vivo in pcDNA3.1(+)-NT3 transfected OEGs.
J Neurosci Methods, 2008 • March 30, 2008
The study introduces a novel in vivo imaging technique for the mouse spinal cord, addressing the challenge of movement artifacts caused by breathing and heartbeat. This technique uses a custom-built s...
KEY FINDING: A novel in vivo technique for two-photon microscopy was developed to allow direct, stable and repetitive imaging of densely populated cells and axons in the living spinal cord of transgenic mice.
J Physiol, 2008 • March 27, 2008
The study investigates the impact of olfactory ensheathing glia (OEG) transplantation on the phenotypic characteristics of fast- and slow-twitch hind limb skeletal muscle in rats with completely trans...
KEY FINDING: OEG transplantation results in hind limb skeletal muscle phenotypes that are generally intermediate between paralyzed and control and different from both.
Neuroscience, 2008 • March 18, 2008
This study investigated the fate of intramedullary primary sensory projections following a motor efferent lesion in rats. The results showed that unilateral avulsion of lumbosacral ventral roots leads...
KEY FINDING: Ventral root avulsion (VRA) induces degeneration of primary afferent collaterals in the dorsal funiculus in the absence of a direct injury to sensory axons.
PLoS ONE, 2008 • March 5, 2008
This study explores the therapeutic potential of peripherally-derived BDNF in promoting the regeneration of ascending sensory neurons following spinal cord injury. The research demonstrates that incre...
KEY FINDING: Conditioning lesion of the sciatic nerve induces regeneration of ascending sensory neurons, and this is blocked by injecting BDNF antiserum in the periphery.
Exp Neurol, 2008 • March 1, 2008
The study examined locomotor recovery and myelin pathology in young and aged rats following contusion SCI, finding that aged rats had delayed recovery and greater pathology. Voluntary exercise, both p...
KEY FINDING: Aged rats exhibit a delayed rate of locomotor recovery following SCI compared to young rats and demonstrate a greater degree of pathology and demyelination.
Phys Ther, 2008 • March 1, 2008
This case report demonstrates that early administration of a load intervention, careful estimation of the loading dose, and detailed surveillance of patient adherence aided in the interpretation of a ...
KEY FINDING: The patient adhered to the electrical stimulation protocol, performing nearly 8,000 soleus muscle contractions per month.