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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Latest Research Summaries

Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.

Showing 11,821-11,830 of 12,052 results

Spinal Cord InjuryNeurologyRehabilitation

An Implanted Upper-Extremity Neuroprosthesis Using Myoelectric Control

J Hand Surg Am, 2008 • April 1, 2008

This study evaluated a second-generation implanted neuroprosthesis controlled by myoelectric signals to restore hand and arm function in individuals with C5/C6 spinal cord injuries. The results demons...

KEY FINDING: EMG signals can be recorded from voluntary muscles even during electrical stimulation of nearby muscles.

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Spinal Cord InjuryRegenerative MedicineRehabilitation

Aspiration of a cervical spinal contusion injury in preparation for delayed peripheral nerve grafting does not impair forelimb behavior or axon regeneration

Exp Neurol, 2008 • April 1, 2008

The study examined whether manipulating a spinal cord contusion injury site prior to transplantation affects behavioral recovery and axonal regeneration. Aspiration of the injury site was performed at...

KEY FINDING: Manipulation of a contusion injury site prior to transplantation does not cause long-lasting forelimb or hindlimb behavioral deficits.

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Regenerative MedicineNeurologyPain Management

Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury

Nat Neurosci, 2008 • April 1, 2008

Systemic artemin treatment caused the regeneration of damaged axons, resulting in virtually complete and long-lasting restoration of nociceptive and sensorimotor functions. Artemin, given in six syste...

KEY FINDING: Systemic artemin administration promotes the regrowth of both myelinated and unmyelinated axons through the dorsal root entry zone (DREZ).

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Spinal Cord InjuryNeurologyGenetics

Ex vivo non-viral vector-mediated neurotrophin-3 gene transfer to olfactory ensheathing glia: effects on axonal regeneration and functional recovery after implantation in rats with spinal cord injury

Neurosci Bull, 2008 • April 1, 2008

This study combined olfactory ensheathing glia (OEG) implantation with ex vivo non-viral vector-based neurotrophin-3 (NT-3) gene therapy to enhance regeneration after thoracic spinal cord injury (SCI)...

KEY FINDING: NT-3 production was seen increased both ex vivo and in vivo in pcDNA3.1(+)-NT3 transfected OEGs.

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Spinal Cord InjuryNeurologyMedical Imaging

Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy

J Neurosci Methods, 2008 • March 30, 2008

The study introduces a novel in vivo imaging technique for the mouse spinal cord, addressing the challenge of movement artifacts caused by breathing and heartbeat. This technique uses a custom-built s...

KEY FINDING: A novel in vivo technique for two-photon microscopy was developed to allow direct, stable and repetitive imaging of densely populated cells and axons in the living spinal cord of transgenic mice.

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Spinal Cord InjuryPhysiologyNeurology

Slow- and fast-twitch rat hind limb skeletal muscle phenotypes 8 months after spinal cord transection and olfactory ensheathing glia transplantation

J Physiol, 2008 • March 27, 2008

The study investigates the impact of olfactory ensheathing glia (OEG) transplantation on the phenotypic characteristics of fast- and slow-twitch hind limb skeletal muscle in rats with completely trans...

KEY FINDING: OEG transplantation results in hind limb skeletal muscle phenotypes that are generally intermediate between paralyzed and control and different from both.

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Spinal Cord InjuryRegenerative MedicineNeurology

Reimplantation of avulsed lumbosacral ventral roots in the rat ameliorates injury-induced degeneration of primary afferent axon collaterals in the spinal dorsal columns

Neuroscience, 2008 • March 18, 2008

This study investigated the fate of intramedullary primary sensory projections following a motor efferent lesion in rats. The results showed that unilateral avulsion of lumbosacral ventral roots leads...

KEY FINDING: Ventral root avulsion (VRA) induces degeneration of primary afferent collaterals in the dorsal funiculus in the absence of a direct injury to sensory axons.

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Spinal Cord InjuryNeurology

Peripherally-Derived BDNF Promotes Regeneration of Ascending Sensory Neurons after Spinal Cord Injury

PLoS ONE, 2008 • March 5, 2008

This study explores the therapeutic potential of peripherally-derived BDNF in promoting the regeneration of ascending sensory neurons following spinal cord injury. The research demonstrates that incre...

KEY FINDING: Conditioning lesion of the sciatic nerve induces regeneration of ascending sensory neurons, and this is blocked by injecting BDNF antiserum in the periphery.

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Spinal Cord InjuryAgingRehabilitation

Voluntary Running Attenuates Age-Related Deficits Following SCI

Exp Neurol, 2008 • March 1, 2008

The study examined locomotor recovery and myelin pathology in young and aged rats following contusion SCI, finding that aged rats had delayed recovery and greater pathology. Voluntary exercise, both p...

KEY FINDING: Aged rats exhibit a delayed rate of locomotor recovery following SCI compared to young rats and demonstrate a greater degree of pathology and demyelination.

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Spinal Cord InjuryRehabilitationMusculoskeletal Medicine

Dose Estimation and Surveillance of Mechanical Loading Interventions for Bone Loss After Spinal Cord Injury

Phys Ther, 2008 • March 1, 2008

This case report demonstrates that early administration of a load intervention, careful estimation of the loading dose, and detailed surveillance of patient adherence aided in the interpretation of a ...

KEY FINDING: The patient adhered to the electrical stimulation protocol, performing nearly 8,000 soleus muscle contractions per month.

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