Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,831-11,840 of 12,052 results
Arch Phys Med Rehabil, 2008 • March 1, 2008
This study evaluated the psychometric properties of the Fatigue Severity Scale (FSS) in persons with spinal cord injury (SCI). The results indicated that the FSS has acceptable reliability with regard...
KEY FINDING: The Fatigue Severity Scale (FSS) demonstrated acceptable internal consistency (Cronbach’s alpha = 0.89) in persons with motor complete SCI.
Neurorehabil Neural Repair, 2008 • March 1, 2008
This study investigates the effect of Nogo-66 receptor antagonist peptide (NEP1-40) on functional recovery and axonal growth after lateral funiculus injury in adult rats. The results showed that NEP1-...
KEY FINDING: NEP1-40 treatment led to recovery in gait compared to controls.
BMC Neuroscience, 2008 • February 24, 2008
This study investigated the expression and function of peripherin in the tuberomammillary (TM) neurons of the mouse hypothalamus, revealing that peripherin is produced by histaminergic neurons in this...
KEY FINDING: Peripherin is expressed in the tuberomammillary neurons of the mouse hypothalamus, specifically within histaminergic neurons.
J Rehabil Res Dev, 2008 • February 1, 2008
The adult mammalian CNS is capable of considerable spontaneous structural and functional plasticity, both in health and disease. Significant evidence from both human and animal studies indicates that ...
KEY FINDING: Reorganization of the CNS, including synaptic plasticity, axonal sprouting, and cellular proliferation, has long been known to spontaneously occur following spinal cord lesions.
Exp Neurol, 2008 • February 1, 2008
Inflammation following SCI has been shown to have both pathogenic and pivotal roles in tissue repair. A challenge for researchers is to learn how to control cross-talk between the nervous and immune s...
KEY FINDING: The inflammatory response in the brain differs from that in the spinal cord in terms of timing, composition, and magnitude.
Exp Neurol, 2008 • February 1, 2008
The failure of axons to regenerate after spinal cord injury remains a significant challenge, but advances have been made in identifying inhibitory proteins in CNS myelin. Elevation of intracellular cA...
KEY FINDING: Elevation of intracellular cAMP levels promotes axonal regeneration in the CNS, overcoming myelin inhibition both in vitro and in vivo.
Exp Neurol, 2008 • February 1, 2008
The review discusses the progress in understanding the mechanisms behind successful axonal regeneration in the peripheral nervous system and the failure of regeneration in the central nervous system. ...
KEY FINDING: Adult axons retain sensitivity to growth factors, and patterns of growth factor sensitivity after injury in adulthood recapitulate developmental patterns.
Exp Neurol, 2008 • February 1, 2008
This study was a replication of a previous study to determine if treatment with NEP1-40 enhances growth of corticospinal and serotonergic axons and enhances locomotor recovery after thoracic spinal co...
KEY FINDING: Treatment with NEP1-40 did not robustly enhance regenerative growth of CST axons or 5HT axons.
J Physiol, 2008 • January 31, 2008
The study investigated the capacity of propriospinal neurons to mediate descending locomotor commands in the absence of direct bulbospinal pathways in neonatal rats. Staggered spinal cord hemisections...
KEY FINDING: Locomotor-like activity could be evoked by brainstem stimulation even with staggered spinal cord hemisections that disrupted long direct pathways.
The Journal of Neuroscience, 2008 • January 30, 2008
This study identifies netrin-1 as a novel oligodendrocyte-associated inhibitor of axonal growth in the adult spinal cord. Netrin-1 and its receptors are expressed in the intact and lesioned adult CNS....
KEY FINDING: Netrin-1 is expressed by mature oligodendrocytes in the adult spinal cord and is enriched near paranodal loops in nodes of Ranvier.