Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,781-11,790 of 12,052 results
The Journal of Neuroscience, 2008 • September 17, 2008
This study demonstrates the critical role of CD11b+ myeloid cells in axon regeneration after neural injury, using a transgenic mouse model for selective cell ablation. The absence of CD11b+ cells lead...
KEY FINDING: Selective ablation of CD11b+ cells impairs axonal regeneration and locomotor function recovery after sciatic nerve injury.
J Cell Sci, 2008 • September 15, 2008
This study demonstrates that specific sulfation in chondroitin sulfate (CS) glycosaminoglycan (GAG) chains mediates neuronal guidance cues and axonal growth inhibition, with chondroitin-4-sulfate (CS-...
KEY FINDING: Chondroitin-4-sulfate (CS-A), but not chondroitin-6-sulfate (CS-C), exhibits a strong negative guidance cue to mouse cerebellar granule neurons, indicating that sulfation at the C4 position of the GalNAc moiety presents a specific negative guidance cue to axons.
J Comp Neurol, 2008 • September 10, 2008
This study investigates the expression of ciliary neurotrophic factor (CNTF) and fibroblast growth factor-2 (FGF-2) after spinal cord injury (SCI) in rats, focusing on their potential roles in endogen...
KEY FINDING: CNTF protein levels continually rose through 28 days post injury in the spinal cord tissue centered on the contusion epicenter.
Neuroscience, 2008 • September 9, 2008
The study examines the role of BDNF in mediating the effects of exercise on motor recovery after cervical hemisection in rats. Results showed that exercise can counteract the decrease in synaptic plas...
KEY FINDING: Exercise normalized the levels of molecules important for synaptic function, such as CREB and synapsin I, in the ipsilateral cervical enlargement of hemisected rats.
J Pain, 2008 • September 1, 2008
This study examined the longitudinal relationships between pain-related beliefs, coping, and social support with pain interference and psychological functioning in individuals with spinal cord injury ...
KEY FINDING: Changes in catastrophizing were significantly associated with changes in pain interference and psychological functioning; increased catastrophizing predicted greater pain interference and poorer psychological functioning.
Stroke, 2008 • September 1, 2008
The study demonstrated that corticospinal tract fibers originating from the contralesional motor cortex sprout into the denervated spinal cord after stroke and bone marrow stromal cells treatment. BMS...
KEY FINDING: Stroke reduced the stimulation threshold evoking ipsilateral forelimb movement.
The Journal of Neuroscience, 2008 • August 20, 2008
This review discusses a study by Lasiene et al. (2008) that examined chronic demyelination in spared axons after spinal cord injury in mice, focusing on actively transporting rubrospinal tract (RST) a...
KEY FINDING: Lasiene et al. (2008) found evidence for complete remyelination of rubrospinal tract (RST) axons 12 weeks after spinal cord injury in mice.
PLoS Medicine, 2008 • August 19, 2008
This study investigates the role of chondroitin sulfate proteoglycan (CSPG) in spinal cord repair, challenging the common belief that it's solely detrimental. The research hypothesizes and demonstrate...
KEY FINDING: Immediate inhibition of CSPG synthesis after spinal cord injury impairs functional motor recovery and increases tissue loss, indicating a beneficial role for CSPG during the acute phase.
The Journal of Neuroscience, 2008 • August 13, 2008
This study investigates the role of Wnt signaling in axon regeneration after spinal cord injury. It was found that normally undetectable Wnt genes are re-expressed following injury, with Wnt1 and Wnt5...
KEY FINDING: The study found that Wnt1 and Wnt5a, known repellents of corticospinal tract (CST) axons, were rapidly and broadly induced in the spinal cord gray matter after unilateral hemisection.
Brain, 2008 • August 8, 2008
This clinical trial evaluated the safety and feasibility of autologous olfactory ensheathing cell (OEC) transplantation in patients with complete thoracic paraplegia. The study followed six transplant...
KEY FINDING: The transplantation of autologous olfactory ensheathing cells into the injured spinal cord was found to be feasible and safe for up to 3 years post-implantation.