Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,771-11,780 of 12,052 results
Neurosci Lett, 2008 • October 10, 2008
The study examined the combined effects of FGF-2 gene therapy and voluntary exercise on axonal regeneration across peripheral nerve gaps in rats. Schwann cells (SCs) were transplanted into nerve gaps,...
KEY FINDING: Exercise for 7 days elevated mRNA levels of regeneration associated proteins (GAP-43 and synapsin I) in lumbar spinal cord and dorsal root ganglia of SC transplanted, in contrast to non-cellular reconstructed rats.
PLoS ONE, 2008 • October 6, 2008
This study examined the effects of human umbilical mesenchymal stem cell (HUMSC) transplantation on spinal cord regeneration in rats after complete spinal cord transection. HUMSCs were transplanted in...
KEY FINDING: Transplantation of HUMSCs led to significant improvements in locomotion three weeks after transplantation, compared to the control group.
Exp Neurol, 2008 • October 1, 2008
The study examined the effects of passive exercise on hyperreflexia in rats with spinal cord transection, comparing exercise initiated before and after hyperreflexia development. Results indicated tha...
KEY FINDING: Passive exercise can modulate spinal circuitry and improve hyperreflexia, even when initiated after the onset of hyperreflexia, but requires a longer duration.
Arch Phys Med Rehabil, 2008 • October 1, 2008
This study has shown that manual wheelchair users with no pain or upper-extremity injury exhibit asymmetry during propulsion, with the magnitude of asymmetry impacted by the wheeling environment. The ...
KEY FINDING: Upper-extremity asymmetry was present within each condition.
JOURNAL OF NEUROTRAUMA, 2008 • October 1, 2008
This study explored the combined effects of acrobatic exercise and magnetic stimulation on functional recovery after spinal cord injury in mice. The researchers induced spinal cord lesions in mice and...
KEY FINDING: Acrobatic exercise combined with exposure to magnetic fields significantly facilitated behavioral recovery in mice following spinal cord injury.
IEEE Trans Neural Syst Rehabil Eng, 2008 • October 1, 2008
This report describes the performance of a 16-channel implanted neuroprosthesis for standing and transfers after spinal cord injury including four-contact nerve-cuff electrodes stimulating the femoral...
KEY FINDING: Responses of the nerve-cuffs were stable and standing times increased by 600% over time-matched values with a similar 8-channel neuroprosthesis.
Mol Cell Neurosci, 2008 • October 1, 2008
This study investigated the impact of deleting the OMgp gene on functional recovery and axonal regeneration after spinal cord injury (SCI) in mice. OMgp-/- mice on a mixed 129BL6 background exhibited ...
KEY FINDING: OMgp-/- mice on a mixed 129BL6 genetic background showed greater functional improvement compared to OMgp+/+ littermates after spinal cord injury.
Neurosci Bull, 2008 • October 1, 2008
This review summarizes the method of cell transplantation via CSF for treatment of SCI. Studies on administration of cells via CSF indicate that the method is safe and convenient. The method is more s...
KEY FINDING: Cell transplantation via CSF is a safe and convenient method for treating SCI, particularly suitable for multiple CNS lesions because it does not involve open lesions.
Journal of Biology, 2008 • September 19, 2008
This study investigates the effects of transplanting astrocytes derived from glial-restricted precursors (GRPs) treated with bone morphogenetic protein-4 (BMP-4) or ciliary neurotrophic factor (CNTF) ...
KEY FINDING: GDAsBMP promote axon regeneration, neuroprotection and robust recovery of function after spinal cord injury, whereas GDAsCNTF do not.
J. Neurosci., 2008 • September 17, 2008
This study investigates the effect of forced limb use after unilateral CST injury on behavioral recovery, compensatory growth, arborization, and synapse formation of the uninjured CST. The results sho...
KEY FINDING: Forced limb use after unilateral CST injury enhances behavioral recovery.