Spinal Cord Research Help
AboutCategoriesLatest ResearchContact
Subscribe
Spinal Cord Research Help

Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

Quick Links

  • Home
  • About
  • Categories
  • Latest Research
  • Disclaimer

Contact

  • Contact Us
© 2025 Spinal Cord Research Help

All rights reserved.

  1. Home
  2. Research
  3. Spinal Cord Injury
  4. Swim Training Initiated Acutely after Spinal Cord Injury Is Ineffective and Induces Extravasation In and Around the Epicenter

Swim Training Initiated Acutely after Spinal Cord Injury Is Ineffective and Induces Extravasation In and Around the Epicenter

JOURNAL OF NEUROTRAUMA, 2009 · DOI: 10.1089=neu.2008.0829 · Published: July 1, 2009

Spinal Cord InjuryCardiovascular ScienceRehabilitation

Simple Explanation

This study investigates the effect of early swim training on recovery after spinal cord injury (SCI) in rats. The researchers compared the effectiveness of initiating swim training shortly after injury versus waiting two weeks. The results showed that starting swim training too soon after the injury was less effective than starting it later. Early training seemed to compromise rehabilitation efforts. The study also found that early swim training increased leakage of substances into the injured spinal cord tissue, suggesting that it may worsen the secondary injury processes.

Study Duration
6-7 Weeks
Participants
Sprague-Dawley rats
Evidence Level
Not specified

Key Findings

  • 1
    Acute swim training (initiated 3 days post-SCI) is less effective than training initiated at 2 weeks post-injury in improving swimming ability.
  • 2
    Acute swim training increases extravasation of macromolecules (luciferase) into the spinal cord parenchyma, indicating increased BSCB permeability.
  • 3
    Even brief swim exercise early after SCI can induce microvascular dysfunction, potentially exacerbating secondary injury.

Research Summary

The study aimed to determine if initiating swim training acutely after spinal cord injury (SCI) is more beneficial than initiating it after 2 weeks. Rats with moderate to severe thoracic contusion SCI were used as subjects. The findings revealed that acute swim training, started 3 days post-SCI, was less effective in improving swimming ability compared to training started at 2 weeks. Moreover, it induced a significant increase in extravasation around the injury site. The results suggest that early re-training may compromise rehabilitation efforts by potentially worsening secondary injury cascades, particularly acute spinal microvascular dysfunction.

Practical Implications

Rehabilitation Timing

Initiating activity-based rehabilitation too early after SCI may be detrimental.

Microvascular Considerations

Rehabilitation strategies should consider the state of the blood-spinal cord barrier (BSCB) and potential for microvascular dysfunction.

Exercise Intensity

Forced exercise acutely after SCI, which can increase cardiovascular output, may have negative consequences.

Study Limitations

  • 1
    Small sample sizes in some experimental groups.
  • 2
    Assessment of spared white matter used different stains across studies.
  • 3
    The study focused on a specific rat model of SCI, limiting generalizability.

Your Feedback

Was this summary helpful?

Back to Spinal Cord Injury