Latest Research Summaries

KEY FINDING: NOD-SCID mice exhibited the greatest locomotor recovery in the open field compared to C57BL/6 and BUB/BnJ mice.

KEY FINDING: Memory was significantly impaired in the hypotensive group compared to the normotensive group (P<0.05).

KEY FINDING: The study quantitatively demonstrates a novel time-dependent multiphasic response of cellular inflammation in the spinal cord after spinal cord injury.

KEY FINDING: Daidzein was identified as a transcriptional inducer of Arg1 through a chemical screen of clinically approved drugs.

KEY FINDING: FM19G11 inhibits HIF1α and HIF2α protein accumulation in human tumor cell lines and stem cells from rodents and humans.

KEY FINDING: Male veterans had a significantly lower HRQOL than non-veterans with SCI, except in physical and social functioning.

KEY FINDING: NSCs are defined as undifferentiated cells that can both self-renew and generate the three major cell types that constitute the CNS, i.e. neurons, astrocytes, and oligodendrocytes, a characteristic known as multipotency.

KEY FINDING: Axon guidance molecules, initially important for neural development, are also present in the mature CNS, influencing network refinement, neuronal excitability, and synaptic function.

KEY FINDING: mRNA gene expression of recurrent disc cells showed increased expression of aggrecan, type I collagen, type II collagen, Sox-9, osteocalcin, and alkaline phosphatase compared to primary herniated lumbar disc cells.

KEY FINDING: Peptide amphiphiles can be designed to self-assemble into nanofibers with specific bioactivity and mechanical properties.