Self-Assembly of Peptide Amphiphiles: From Molecules to Nanostructures to Biomaterials

Peptide amphiphiles (PAs) are molecules that combine surfactant properties with bioactive peptide functions, self-assembling into diverse nanostructures. These PAs can form one-dimensional nanofibers under physiological conditions, making them useful for biomedical applications like tissue engineering and drug delivery. The molecular self-assembly is used as a tool to produce these PA nanostructures, translating this technology into therapies for spinal cord injury, angiogenesis, and tissue regeneration.

• 1
  Peptide amphiphiles can be designed to self-assemble into nanofibers with specific bioactivity and mechanical properties.
• 2
  PA nanofibers can be used to promote neural regeneration, hard tissue regeneration, and angiogenesis in vivo.
• 3
  The self-assembly of PAs can be controlled through molecular design, environmental conditions, and co-assembly with other molecules.