Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,561-11,570 of 12,052 results
Spinal Cord, 2010 • March 1, 2010
This study evaluated the psychometric properties of the International Spinal Cord Injury Basic Pain Data Set (ISCIBPDS) items when used as self-report measures by individuals with spinal cord injury (...
KEY FINDING: The ISCIBPDS items measuring pain interference, intensity, site(s), frequency, duration, and timing are useful and valid for individuals with SCI and chronic pain.
JOURNAL OF NEUROTRAUMA, 2010 • March 1, 2010
This study demonstrates that delayed, post-injury administration of 17b-estradiol reduces secondary damage and promotes functional recovery after SCI. Eliminating testicular-derived androgens increase...
KEY FINDING: Post-SCI administration of 17b-estradiol improves hindlimb locomotion.
Exp Neurol, 2010 • March 1, 2010
This study assessed the chronic effects of low thoracic hemisection on the cough reflex in cats. The major finding is that expiratory motor drive to abdominal muscles is not significantly impaired dur...
KEY FINDING: Expiratory motor drive to abdominal muscles is not significantly impaired during cough in cats that are chronically hemisected in the lower thoracic spinal cord.
PNAS, 2010 • February 23, 2010
This study addresses the challenge of delivering chABC, an enzyme that promotes nerve regeneration after spinal cord injury, by thermostabilizing it with trehalose and using a hydrogel-microtube syste...
KEY FINDING: Trehalose significantly enhances the thermal stability of chABC, allowing it to remain active at 37 °C for up to 4 weeks in vitro.
BMC Neuroscience, 2010 • February 18, 2010
The study aimed to use RNAi to knock down Semaphorin receptors Npn-1 and Npn-2 in spinal nerve tracts to promote axon regeneration after spinal cord injury. Effective shRNAs were developed to knock do...
KEY FINDING: shRNAs can effectively knock down Npn-1 and Npn-2 expression in neuronal cell lines in vitro using lentiviral delivery.
Curr Opin Organ Transplant, 2010 • February 1, 2010
iPS cells hold great promise due to their potential to circumvent ethical and immunological challenges associated with ES cells. However, their use is limited by reprogramming efficiency and therapeut...
KEY FINDING: Somatic cells can be reprogrammed to a pluripotent state using retroviral transduction of only 4 genes: Sox2, Oct4/Pou5f1, c-Myc, and Klf4. These are termed the “Yamanaka factors”.
J Neurosci Res, 2010 • February 1, 2010
This study investigates the effect of immediate anti-TNF-α (etanercept) therapy on nerve regeneration after sciatic nerve crush injury in rats. The researchers found that TNF-α mRNA expression increas...
KEY FINDING: TNF-α mRNA expression is induced at 1 day and returned to baseline at 5 days after injury in nerve and the corresponding dorsal root ganglia (DRG).
Glia, 2010 • February 1, 2010
This study investigates the molecular mechanisms underlying the upregulation of CHL1 expression in reactive astrocytes following spinal cord injury (SCI). It demonstrates that bacterial lipopolysaccha...
KEY FINDING: LPS upregulates CHL1 expression in astrocytes via a PI3K/PKCδ-dependent pathway.
J Electromyogr Kinesiol, 2010 • February 1, 2010
This study provides a characterization of daily living and mobility activities associated with manual wheelchair propulsion. It identifies activities that result in higher shoulder kinetics compared t...
KEY FINDING: Weight relief resulted in significantly higher forces compared to other activities.
Neurobiol Dis, 2010 • February 1, 2010
Recovery from brain and spinal cord disorders is an area of active research that seeks to maximize improvement after neuronal damage. Brain maps, particularly motor maps, are reorganized after injury,...
KEY FINDING: Experience-dependent processes, including disinhibition and synapse stabilization, are crucial for recovery after CNS injury.