Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 61-70 of 7,812 results
Exp Neurol, 2012 • May 1, 2012
This study investigated the potential of salmon fibrin as an injectable scaffold for treating spinal cord injury in rats. The researchers compared the effects of salmon fibrin, human fibrin, and no tr...
KEY FINDING: Rats treated with salmon fibrin exhibited significantly improved recovery of both locomotor and bladder function compared to those treated with human fibrin or left untreated.
J. Cell. Mol. Med., 2012 • August 1, 2012
This study demonstrated neuroprotective effects of Erythropoietin (EPO) in a mouse model of ischaemic spinal cord injury (SCI). EPO treatment improved neurological function and reduced motor neuron lo...
KEY FINDING: Erythropoietin-treated mice with complete paralysis demonstrated significant improvement of neurological function between day 2 and 7, compared to saline-treated mice with complete paralysis.
Brazilian Journal of Medical and Biological Research, 2012 • January 16, 2012
This study evaluated the efficacy of mononuclear cells from human umbilical cord blood in promoting functional recovery after spinal cord injury in rats. Cells were transplanted either directly into t...
KEY FINDING: Transplantation of mononuclear cells from human umbilical cord blood promoted functional recovery in rats with spinal cord injury.
Exp Neurol, 2012 • May 1, 2012
This review highlights experimental strategies to restore respiratory function after spinal cord injury (SCI), focusing on the innate plasticity and capacity for adaptation in the respiratory system a...
KEY FINDING: Pharmacological treatments, such as theophylline, can partially restore function to the paralyzed hemidiaphragm by increasing respiratory drive.
PLoS ONE, 2011 • December 21, 2011
This study demonstrates that the glial scar matrix serves as a necessary scaffold, skewing monocytes towards the resolving phenotype, characterized by the production of the anti-inflammatory cytokine ...
KEY FINDING: The glial scar matrix CSPG skews infiltrating monocytes towards a resolving, anti-inflammatory phenotype.
TISSUE ENGINEERING: Part A, 2012 • February 7, 2012
The study investigates the potential of electrospun collagen nanofibers for spinal cord injury (SCI) treatment, addressing the limitations of current methods due to the inhibitory microenvironment afte...
KEY FINDING: Astrocytes cultured on collagen nanofibers showed suppressed proliferation and GFAP expression compared to those on 2D controls.
Exp Neurol, 2012 • May 1, 2012
This study compares the efficacy of peripheral nerve conditioning lesions to cAMP elevations on central sensory axonal regeneration when administered either before or after cervical spinal cord lesion...
KEY FINDING: Conditioning lesions are more effective than cAMP elevations on central axonal regeneration, especially when combined with cellular grafts and viral neurotrophin delivery.
Brain, 2012 • February 1, 2012
This study investigates the therapeutic plasticity of neural stem/precursor cells (NPCs) after focal implantation in a severely contused spinal cord. The findings identify a precise window of opportun...
KEY FINDING: Subacute transplantation of neural stem/precursor cells (NPCs) led to significant recovery of locomotor functions in mice with spinal cord injury.
Eur J Neurosci, 2012 • February 1, 2012
Adult zebrafish can regenerate spinal cords, unlike mammals. This study investigates the role of cysteine and glycine-rich protein 1 (CRP1) in this process. Microarray analysis identified CRP1 as upre...
KEY FINDING: CRP1 (csrp1a) is upregulated in neurons after spinal cord injury (SCI) in zebrafish. The upregulation occurs in regenerative nuclei like NMLF, IMRF, and SRF.
Journal of Tissue Engineering, 2011 • January 1, 2011
The injured human CNS has only limited ability to recover after injury, with little recovery correlating to long-distance axonal regeneration. Removal of glial-inhibitory molecules has not dramaticall...
KEY FINDING: Injured axons must detect damage to initiate a regenerative response, triggering calcium-based and retrograde transport-based signals.