Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 51-60 of 7,812 results
Orthopaedic Surgery, 2009 • May 1, 2009
This study evaluated the efficacy of cell therapy using fetal spinal cord cells (FSCC) and/or Schwann cells (SC), with or without growth factors (NGF and BDNF), in a rat model of spinal cord injury. T...
KEY FINDING: A combination of FSCC and SC resulted in better recovery than either cell type alone, suggesting a synergistic effect.
Indian Journal of Radiology and Imaging, 2011 • August 1, 2011
This study investigates the feasibility of spinal tractography and fractional anisotropy (FA) value comparison in spinal cord injury patients versus a control group. DTI was performed on 29 subjects (...
KEY FINDING: The mean FA value was 0.550±0.09 in the control group and 0.367±0.14 in the patients; this difference was statistically significant (P=0.001).
Exp Neurol, 2012 • February 1, 2012
This study systematically analyzed astrocyte differentiation from glial-restricted precursors (GRPs) using different methods and treatments (FBS, BMP-4, CNTF). The resulting astrocytes were characteri...
KEY FINDING: FBS and BMP-4 treatments led to highly differentiated astrocytes, while CNTF resulted in an intermediate state with immature markers.
J Gene Med, 2012 • January 1, 2012
This study investigates the potential of adeno-associated virus (AAV) vectors to deliver therapeutic transgenes and promote axon regeneration in brainstem neurons following spinal cord injury. The res...
KEY FINDING: AAV-EGFP effectively labeled brainstem neurons and their axons, allowing for visualization of their regeneration into the Schwann cell bridge.
The Journal of Neuroscience, 2011 • November 23, 2011
This study investigates the role of keratan sulfate (KS) in plasticity after spinal cord injury (SCI) by using keratanase II (K-II), an enzyme that specifically degrades KS in vivo. The main finding i...
KEY FINDING: K-II, an enzyme that specifically degrades KS, promoted motor and sensory function recovery in rats after SCI.
The Journal of Spinal Cord Medicine, 2011 • January 1, 2011
This case report presents the postmortem findings of a 65-year-old woman with CSM who underwent laminoplasty. The autopsy revealed significant structural changes in the spinal cord, including atrophy ...
KEY FINDING: Atrophy was observed in the ventral gray matter at the C4-C5 level, causing a triangular shape in cross-sections of the spinal cord.
Biomaterials, 2012 • February 1, 2012
The study investigates the delivery of lentiviral vectors from multiple channel bridges as a combinatorial approach to promote regeneration in the injured spinal cord. Lentivirus induced expression of...
KEY FINDING: Lentivirus-loaded bridges resulted in localized protein expression within the injury site, with lower expression in adjacent tissue, with expression maximal at the implantation site.
The Journal of Clinical Investigation, 2012 • January 1, 2012
This study demonstrates the neuroregenerative potential of human dental pulp stem cells (DPSCs) in treating spinal cord injury (SCI). DPSCs were transplanted into rats with completely transected spina...
KEY FINDING: Transplantation of human dental pulp stem cells (DPSCs) into completely transected rat spinal cords resulted in marked recovery of hind limb locomotor functions compared to controls.
Trends Neurosci, 2012 • March 1, 2012
The review focuses on recent advances in sensory axon regeneration, particularly the ability of sensory axons to reconnect with their original synaptic targets after spinal cord injury. It discusses t...
KEY FINDING: Inactivation of inhibitory molecules like Nogo and chondroitin sulfate proteoglycans, as well as the administration of neurotrophic factors such as NGF, NT-3, GDNF, and artemin, can promote anatomical and functional regeneration across the DREZ.
British Journal of Pharmacology, 2012 • May 1, 2012
This study investigates the effect of ethyl pyruvate on spinal cord repair in a rat model of SCI, focusing on its impact on astrogliosis, neuroinflammation, neuronal survival, and axonal regeneration....
KEY FINDING: Ethyl pyruvate treatment improved locomotor recovery in rats after spinal cord injury, as evidenced by BBB scoring, horizontal-ladder test, and foot-print analyses.