Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 41-50 of 7,812 results
PLoS ONE, 2011 • September 13, 2011
This study provides evidence that soluble inhibitors of EphA4 function can be used therapeutically to promote recovery from spinal cord injury in mice. Two EphA4 blockers, ephrin-A5-Fc and EphA4-Fc, w...
KEY FINDING: Administration of either ephrin-A5-Fc or EphA4-Fc for 2 weeks following spinal cord injury resulted in substantial axonal regeneration, with many axons entering and crossing the lesion site.
Front. Hum. Neurosci., 2024 • September 10, 2024
The editorial highlights the global burden of TBI and SCI, emphasizing the need for innovative and effective neurorehabilitation interventions to improve functional recovery and social reintegration f...
KEY FINDING: Mild TBI survivors often experience psychiatric comorbidities like anxiety, depression, and PTSD, along with chronic pain and cardiovascular issues.
Brain Res, 2011 • October 18, 2011
This study investigates the effectiveness of a combination therapy involving acute administration of NBQX (an AMPA/kainate receptor antagonist) and delayed transplantation of neuronal precursors (NRP/...
KEY FINDING: The combined treatment (NBQX & NRP/GRP) accelerated the recovery of bladder contraction after spinal cord injury compared to controls.
Exp Neurol, 2012 • February 1, 2012
This study was designed as a direct replication of a previous experiment that reported inosine promotes the growth of corticospinal tract (CST) axons across the midline of the spinal cord after injury...
KEY FINDING: Intracortical delivery of inosine did not trigger extensive growth of CST axons across the astroglial boundary at the midline of the dorsal column following unilateral pyramidotomy.
PNAS, 2011 • October 4, 2011
This study investigated the therapeutic potential of human-induced pluripotent stem cell-derived neurospheres (hiPSC-NSs) for treating spinal cord injury (SCI) in mice. The findings demonstrated that ...
KEY FINDING: Transplanted hiPSC-NSs survived, migrated, and differentiated into neurons, astrocytes, and oligodendrocytes within the injured spinal cord of mice.
PLoS ONE, 2011 • September 21, 2011
This study investigates the role of microglia in axonal regeneration after spinal cord injury (SCI) and identifies RGMa as a key molecule mediating the inhibitory effects of activated microglia on axo...
KEY FINDING: Activated microglia inhibit neurite outgrowth and induce growth cone collapse of cortical neurons in vitro, but only when there is direct contact between microglia and neurons.
The Journal of Neuroscience, 2011 • October 5, 2011
This study identifies leukocyte common antigen-related phosphatase (LAR) as a functional receptor for chondroitin sulfate proteoglycans (CSPGs), which are known axon growth inhibitors. The researchers...
KEY FINDING: CSPGs bind to the LAR phosphatase with high affinity in COS-7 cells, indicating a direct interaction between these molecules.
Cell Death and Disease, 2011 • October 13, 2011
The study provides a detailed anatomical description of serotonergic projections and 5-HT1A receptor distribution in the human spinal cord at thoracic and lumbar levels. The findings reveal similariti...
KEY FINDING: Serotonergic profiles are present in the ventral horn, surrounding motoneurons, and also contact their presumptive dendrites at the lumbar level.
Frontiers in Molecular Neuroscience, 2011 • September 29, 2011
This study investigated changes in gene expression in the sensorimotor cortex of rats following spinal cord injury (SCI) and treatment with an anti-scarring treatment (AST). Microarray analysis reveal...
KEY FINDING: Spinal cord injury induces significant changes in cortical gene expression as early as 1 day post-injury, with a peak at 21 days.
Crit Care Med, 2012 • February 1, 2012
Post-SCI, early systemic hypothermia provided significant neuroprotection weeks after injury via improved sensory electrophysiological signals in rats. This was accompanied by higher motor behavioral ...
KEY FINDING: Hypothermia group showed significantly higher SSEP amplitudes post-injury compared to controls.