Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 2,851-2,860 of 7,812 results
Chinese Neurosurgical Journal, 2022 • January 1, 2022
This case report describes the successful microsurgical repair of a severed thoracic spinal cord in a 34-year-old man who sustained a penetrating stab injury. The patient presented with Brown-Séquard ...
KEY FINDING: Microsurgical repair of a severed thoracic spinal cord is technically feasible and can lead to significant functional recovery.
Adv. Healthcare Mater., 2022 • August 25, 2022
The study addresses the challenge of delivering therapeutic proteins, specifically ChABC, to spinal cord injuries (SCIs) due to their instability. It explores a non-viral mRNA-based method using miner...
KEY FINDING: MCM-mediated mRNA delivery is an efficient non-viral gene delivery method in primary neural cells in vitro and enabled localized transgene expression in the glial scar in vivo.
Spinal Cord Series and Cases, 2022 • July 17, 2022
The case report describes a rare instance of sub-acute post-traumatic ascending myelopathy (SPAM) in a 22-year-old male who experienced significant neurological deterioration after spinal cord injury ...
KEY FINDING: The patient experienced a rapid progression of neurological level, ascending more than four segments from T12 to T2 within a few weeks post-surgery.
Cells, 2022 • July 18, 2022
This study used RNA sequencing to analyze gene expression changes in rats at five time points after spinal cord injury (SCI): 1 hour, 1 day, 1 week, 1 month, and 3 months. The researchers identified d...
KEY FINDING: The inflammatory response was increased at 1 hour and 1 day after SCI, while the integral component of the synaptic membrane was increased at 1 day.
Int. J. Environ. Res. Public Health, 2022 • July 19, 2022
This systematic review aimed to evaluate the effectiveness of combining virtual reality (VR) and robotics in treating patients with spinal cord injury (SCI). The review included six studies, involving...
KEY FINDING: Improvements were noted in upper limb mobility, specifically in shoulder and upper arm movement.
J. Pers. Med., 2022 • June 30, 2022
Cardiometabolic risk and CMS are a significant global public health crisis for the population with SCI. Many people with SCI present with cardiometabolic risk factors, the most serious of which is obe...
KEY FINDING: Obesity after SCI is characterized not just by increased body fat but by the dysregulation of adipose tissue, leading to inflammation, insulin resistance, and other metabolic issues.
J. Pers. Med., 2022 • July 6, 2022
The dual diagnosis of TBI and SCI is under-recognized and requires special attention to meet the challenge of properly managing these issues. Comorbidities of the two conditions may overlap, causing s...
KEY FINDING: Estimates of concurrent TBI in patients with primary traumatic SCI range from 12.5 to 74.2%, based on the diagnostic criteria utilized.
J. Pers. Med., 2022 • July 7, 2022
Autonomic dysfunction is a profound change following SCI, often overlooked but crucial for quality of life. SCI leads to sympathetic blunting and parasympathetic dominance, causing various cardiovascu...
KEY FINDING: SCI disrupts supraspinal influence on the ANS, leading to sympathetic blunting and parasympathetic dominance, resulting in various dysfunctions.
J. Pers. Med., 2022 • July 11, 2022
The pathophysiology of SCI involves structural disruption, primary traumatic injury, and secondary injury mechanisms, leading to cell death, inflammation, and long-term complications. Clinical classif...
KEY FINDING: Acute SCI pathophysiology involves primary instantaneous injury and secondary progressive injury processes, where secondary damage can be attenuated.
J. Pers. Med., 2022 • July 12, 2022
Spinal cord injury leads to motor paralysis and sensory loss, increasing the risk of pressure injuries, which are further complicated by comorbidities. Effective management of pressure injuries in SCI...
KEY FINDING: Individuals with complete SCI are 4.5 times more likely to acquire a pressure injury during acute hospitalization than those with incomplete SCI. This highlights the increased vulnerability associated with more severe spinal cord injuries.