Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 171-180 of 7,812 results
EMBO reports, 2013 • August 9, 2013
The study investigates the role of STAT3 in corticospinal tract (CST) remodeling after spinal cord injury (SCI). It finds that sustained activation of STAT3 enhances remodeling of lesioned CST fibers ...
KEY FINDING: Endogenous STAT3 expression after spinal cord injury is transient and does not significantly contribute to axonal remodeling.
PLoS ONE, 2013 • July 23, 2013
This study demonstrates that P45, a member of the death domain superfamily, interacts with FADD and diminishes Fas-FADD mediated death signaling. The DED of FADD is required for the complex formation ...
KEY FINDING: P45 forms a complex with FADD, and the DED domain of FADD is required for this interaction.
PLoS ONE, 2013 • August 2, 2013
This study investigates the role of SnoN, a developmentally-regulated transcription factor, in promoting axonal regeneration after spinal cord injury. The research aims to address the limited growth c...
KEY FINDING: SnoN overexpression in adult DRG neurons significantly enhances neurite growth in vitro.
PLoS ONE, 2013 • August 12, 2013
The study investigated spinal cord injuries in developing opossums at postnatal days 7 and 28 to understand neuronal circuit remodeling and locomotor recovery. P7-injured opossums showed axonal regrow...
KEY FINDING: P7-injured animals regrew supraspinal and propriospinal axons through the injury site and recovered near-normal coordinated overground locomotion with altered gait characteristics.
Journal of Pharmacology and Pharmacotherapeutics, 2013 • July 1, 2013
The study introduces a cost-effective customized impact device for creating experimental spinal cord injuries in rats, addressing the financial limitations faced by researchers in developing countries...
KEY FINDING: The customized impact device produced consistent lesion effects in rats, as evaluated by behavioral scoring methods.
PLoS ONE, 2013 • August 13, 2013
The administration of high doses of minocycline was deleterious for motor neuron survival. In addition, it inhibited microglial activation and impaired glial viability and migration. These data sugges...
KEY FINDING: Prolonged minocycline administration decreased the survival of motor neurons in the organotypic cultures.
PLoS ONE, 2013 • August 19, 2013
The study developed a neonatal mouse spinal cord compression (SCC) injury model to investigate adaptive plasticity and human stem cell integration after injury. The model allows for high-throughput as...
KEY FINDING: Dramatic degeneration of axons and synaptic contacts was evident within 24 hours of SCC, and loss of neurons in the injured segment was evident for at least a month thereafter.
PLoS ONE, 2013 • August 1, 2013
This study investigates the therapeutic potential of BMSC-conditioned medium (CM) in a rat model of spinal cord injury (SCI), focusing on its effects on secondary injury processes. In vitro experiment...
KEY FINDING: BMSC-conditioned medium (BMSC-CM) protects neurons from apoptosis in vitro, suggesting a neuroprotective effect.
The Journal of Neuroscience, 2013 • September 25, 2013
This study demonstrates that suppressing PTEN expression with shRNA promotes the regeneration of injured CST axons after SCI. The regenerating axons form anatomical synapses and interact with the extr...
KEY FINDING: Suppression of PTEN expression using shRNA promotes regeneration of injured corticospinal tract (CST) axons after spinal cord injury (SCI).
JOURNAL OF NEUROTRAUMA, 2014 • March 15, 2014
The study demonstrates the feasibility of using a regulatable L1 expression system in human embryonic stem cell-derived neural stem cells (H9NSCs) to improve cell-based therapy for spinal cord injury ...
KEY FINDING: Regulatable L1 expression system: The study successfully developed a nonviral doxycycline-inducible system to control L1 expression in human neural stem cells (H9NSCs).