Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 161-170 of 7,812 results
Neurosci Bull, 2013 • August 1, 2013
The study investigated functional recovery and anatomical regeneration after spinal cord transection in rats at different developmental stages (PN1, PN7, PN14, and adult). Neonatal rats (PN1 and PN7) ...
KEY FINDING: Rats transected at PN1 and PN7 showed a significant level of stepping function after complete spinal cord transection, unlike PN14 and adult rats.
Clinical and Experimental Immunology, 2013 • January 1, 2013
This study investigates the neuroprotective effects of C5a after spinal cord injury (SCI). It examines the impact of C5a administration at different time points relative to the injury, both in vivo an...
KEY FINDING: Delayed administration of C5a (24 hours post-injury) significantly improved locomotor function in mice after SCI.
Neurosci Bull, 2013 • August 1, 2013
Glial scar formation after spinal cord injury involves complex molecular and cellular processes. It involves the misalignment of astrocytes and deposition of inhibitory molecules, impacting axonal re...
KEY FINDING: Glial scars are composed of fibrotic and glial tissues, with the glial scar mainly astrocytic, forming a physical barrier to axonal growth after SCI. The glial scar has increased expression of ECM components, predominantly secreted by reactive astrocytes.
Neurosci Bull, 2013 • August 1, 2013
Spinal cord injury (SCI) results in permanent loss of function. A contributing factor to the permanence of SCI is that damaged axons do not regenerate, which prevents the re-establishment of axonal ci...
KEY FINDING: Axonal regeneration is considered an important repair mechanism for the injured spinal cord and materials that have shown most promise to elicit an axonal regeneration response to foster functional restoration after SCI are reviewed.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013 • September 13, 2013
This study identifies a novel mechanism for promoting axonal sprouting and regeneration in the CNS in vivo: the targeting of LRP1 receptors. Agonists of this LDL gene family receptor result in activat...
KEY FINDING: LRP1 activation promotes neurite outgrowth from adult DRG sensory neurons under both permissive and non-permissive conditions.
Molecular Therapy—Nucleic Acids, 2013 • July 23, 2013
The study demonstrates that AAV can be retrogradely transported by axons severed by SCI to transduce supraspinal neurons. Intraspinal injection of AAV near the injury site resulted in transduction of ...
KEY FINDING: AAV injected into the spinal cord near an injury site can travel to the brain and deliver genes to nerve cells.
Exp Neurol, 2013 • October 1, 2013
This study examined the pre-clinical potential of NPCs derived from human induced pluripotent stem cells (hiPSCs) to repair chronic SCI. hiPSCs were differentiated into region-specific (i.e. caudal) N...
KEY FINDING: Caudalized hiPSC-NPCs can be successfully transplanted into an early chronic cervical SCI model and survive for up to two months post-transplant without risk of overgrowth or loss of function.
Neurosci Bull, 2013 • August 1, 2013
This review provides an overview of different animal models used in spinal cord injury research, specifically focusing on axon regeneration. It discusses the pros and cons of each model, including con...
KEY FINDING: Rat models mimic human SCI pathology better due to the formation of cystic cavities, making them suitable for preclinical studies of cellular and pharmacological therapies.
Neurosci Bull, 2013 • August 1, 2013
Membrane disruption has serious downstream structural and functional consequences in the mechanical injury of neuronal tissue. PEG-mediated resealing of cell membranes is a practical method to repair ...
KEY FINDING: Polyethylene glycol (PEG) can reseal axonal membranes following various injuries in multiple in vitro and in vivo injury models.
Neurosci Bull, 2013 • August 1, 2013
This review provides an overview of the anatomical and electrophysiological changes occurring within the spinal cord that lead to, or are associated with the re-expression of locomotion in spinally-tr...
KEY FINDING: Salamanders can recover locomotor function after complete spinal cord transection due to the regeneration of descending pathways.