Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 151-160 of 7,812 results
Iranian Biomedical Journal, 2013 • July 1, 2013
This study aimed to evaluate the potential of bone marrow-derived Schwann cells (SCs) to improve functional recovery in rats after spinal cord injury (SCI). Mesenchymal stem cells (MSCs) were differen...
KEY FINDING: Differentiated cells showed Schwann cell morphology and markers in vitro.
J Neuropathol Exp Neurol, 2013 • July 1, 2013
The study aimed to determine if brief electrical stimulation of transplanted embryonic ventral spinal cord cells could improve motoneuron survival, axon regeneration, muscle reinnervation, and functio...
KEY FINDING: Brief electrical stimulation at 1 Hz for 1 hour significantly increased the number of myelinated axons.
J Control Release, 2013 • September 28, 2013
The study investigates the use of polysaccharide-modified PLG scaffolds for controlled lentivirus delivery to enhance tissue regeneration, particularly in spinal cord injuries. Surface modification wi...
KEY FINDING: Chitosan and heparin modification of PLG scaffolds significantly enhanced lentivirus association and transduction efficiency in vitro compared to hyaluronan and control scaffolds.
BMC Surgery, 2013 • June 24, 2013
This study aimed to compare the efficacy of peripheral nerve (PN) transplantation and ventral root re-implantation in restoring motor neuron function after brachial plexus injury in rats. The results ...
KEY FINDING: Re-implantation of ventral roots significantly increased the survival and regeneration of motoneurons compared to PN graft transplantation.
The Journal of Spinal Cord Medicine, 2013 • May 1, 2013
This systematic review analyzes studies using biomaterials to promote neuronal regeneration after spinal cord injury (SCI) in rodents. The review focuses on multimodal interventions combining biodegra...
KEY FINDING: Biomaterial-based interventions resulted in modest functional improvement in rodent models of SCI.
The Journal of Spinal Cord Medicine, 2013 • May 1, 2013
The study analyzes mRNA expression levels of p75NTR, Trk A, and caspase-9 in a rat model of spinal cord injury (SCI) at different time points and locations around the injury site. Results show a compl...
KEY FINDING: The expression of p75NTR, Trk A, and caspase-9 mRNA changes after SCI, with the greatest variation observed in the center regions of the injury.
Cerebral Cortex, 2014 • June 28, 2013
The study demonstrates that direct cortical delivery of the PKC inhibitor GÖ6976 promotes CST axonal regeneration and enhances forelimb functional recovery in rats with cervical spinal cord injuries. ...
KEY FINDING: Cortical delivery of GÖ6976 reduced injury-induced activation of conventional PKCα and PKCβ1 in CST neurons.
International Journal of Nanomedicine, 2013 • June 20, 2013
The study investigates the therapeutic potential of iron oxide nanoparticles (IONPs) and magnetic field (MF) exposure in rats with complete spinal cord injury (SCI). Locomotor and sensorimotor assessm...
KEY FINDING: IONP implantation combined with MF exposure significantly reduced functional deficits after spinal cord injury in rats.
The Journal of Neuroscience, 2013 • July 3, 2013
The study used a multistep screening approach to discover genes specifically contributing to the regeneration-promoting properties of OECs. Microarray screening and functional characterization identif...
KEY FINDING: Sixteen genes in OECs (ADAMTS1, BM385941, FZD1, GFRA1, LEPRE1, NCAM1, NID2, NRP1, MSLN, RND1, S100A9, SCARB2, SERPINI1, SERPINF1, TGFB2, and VAV1) significantly reduced outgrowth of cocultured DRG neurons.
Neuroscience, 2013 • October 10, 2013
Ventral root avulsion injury in the rhesus macaque resulted in a marked loss of axotomized motoneurons and an astroglial reaction in the ventral horn. The avulsed ventral roots undergoing initial Wall...
KEY FINDING: A lumbosacral VRA injury resulted in retrograde motoneuron loss and astrocytic glial activation in the ventral horn.