Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 141-150 of 7,812 results
The Journal of Neuroscience, 2013 • March 27, 2013
The study demonstrates that a continuous growth-promoting pathway, constructed by grafting Schwann cells overexpressing GDNF within and caudal to a spinal cord injury, leads to anatomical regeneration...
KEY FINDING: Grafted Schwann cells overexpressing GDNF promoted regeneration of descending propriospinal (DPST) axons through and beyond the lesion gap of a spinal cord hemisection.
JOURNAL OF NEUROTRAUMA, 2013 • June 15, 2013
The present results establish that electrical stimulation of embryonic neurons for 1 h immediately after transplantation increases neuron, motoneuron, and myelinated axon counts, resulting in long-ter...
KEY FINDING: Acute stimulation of the transplant increased the median number of NeuN-positive neurons after 10 weeks.
Neurosci Bull, 2013 • August 1, 2013
After spinal cord injury (SCi), re-establishing functional circuitry in the damaged central nervous system (CNS) faces multiple challenges including lost tissue volume, insufficient intrinsic growth c...
KEY FINDING: Combinatorial therapies with ChABC have shown synergistic effects with cell implantation in enhancing functional recovery after spinal cord injury, improving graft integration and axon regeneration across the lesion.
JOURNAL OF NEUROTRAUMA, 2013 • June 15, 2013
This study demonstrates that blocking EphA4 activation with EphA4-Fc improves functional outcomes and promotes structural changes in a rat model of contusive spinal cord injury. The researchers found ...
KEY FINDING: EphA4-Fc treatment significantly improves locomotor function in rats after contusive spinal cord injury, as measured by the ledged tapered balance beam task and open-field testing.
Neuroscience, 2013 • August 15, 2013
Reticulospinal (RS) neurons are critical for initiation of locomotor behavior, and following spinal cord injury (SCI) in the lamprey, the axons of these neurons regenerate and restore locomotor behavi...
KEY FINDING: Activation of cAMP pathways with forskolin or dbcAMP stimulated neurite outgrowth of RS neurons in culture in a PKA-dependent manner.
JOURNAL OF NEUROTRAUMA, 2013 • June 15, 2013
This study meticulously characterized the phenotypic diversity and plasticity of hGRP prepared by a Good Manufacturing Practice (GMP) production standard for possible clinical application. The study f...
KEY FINDING: hGRP and hGRP-derived astrocytes showed excellent survival and expressed astrocyte markers after transplantation into a spinal cord lesion.
PLoS ONE, 2013 • April 24, 2013
This study compares the potential of OECs from the olfactory bulb (OB-OECs) and olfactory mucosa (OM-OECs) for spinal cord repair after severe SCI. The results demonstrate that transplantation of OECs...
KEY FINDING: Transplantation of OECs from OB or OM induces electrophysiological and functional recovery after spinal cord injury.
PLoS ONE, 2013 • May 7, 2013
The study investigates the effects of a snake venom-derived fibrin sealant on functional recovery, neuronal survival, synaptic plasticity, and glial reaction after ventral root reimplantation. The res...
KEY FINDING: Root reimplantation with fibrin sealant enhances motor recovery and improves neuronal survival.
Iranian Red Crescent Medical Journal, 2013 • February 1, 2013
This study aimed to assess the therapeutic potential of cholinergic neuron-like cells (CNLs) derived from bone marrow stromal cells (BMSCs) in a rat model of spinal cord contusion. The results demonst...
KEY FINDING: Rats treated with CNLs showed a higher rate of improvement in motor function compared to those treated with BMSCs alone or the untreated group, as measured by the BBB test.
Journal of Visualized Experiments, 2013 • May 9, 2013
The study introduces a novel technique for creating controlled cervical spinal cord laceration injuries in mice. This method incorporates vertebral facet fixation for spine stabilization, enhanced spi...
KEY FINDING: The described method allows for a reproducible cervical spinal cord laceration injury in mice with an accuracy of ±0.01 mm in lesion depth.