Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 131-140 of 7,812 results
JOURNAL OF NEUROTRAUMA, 2013 • May 15, 2013
This study shows the pattern of Ryk receptor expression in the unlesioned adult spinal cord, in neurons (mainly in the ventral horns), astrocytes close to the pial surface, and blood vessels. We also ...
KEY FINDING: Ryk mRNA expression increased from 24 hours post-injury until 7 days post-injury.
PLoS ONE, 2013 • January 21, 2013
This study provides evidence that agmatine treatment leads to lasting improvements of structure and function after spinal cord injury (SCI). Agmatine modulates BMP-2/4/7 expressions in neurons, oligod...
KEY FINDING: Agmatine treatment improved locomotor recovery and bladder function in mice with SCI.
Eur J Neurosci, 2013 • April 1, 2013
The study demonstrates that electrical stimulation of the motor cortex promotes significant axon outgrowth to the spinal cord, red nucleus, and cuneate nucleus after unilateral pyramidotomy in rats. S...
KEY FINDING: Electrical stimulation of the motor cortex after spinal cord injury increases axon length in both the spinal cord and magnocellular red nucleus.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2013 • January 1, 2013
This study established a novel rat SCI model involving spinal cord transection and spine shortening to ensure complete axonal transection. The results indicated that axonal regeneration was inhibited ...
KEY FINDING: Uncoordinated movements of the hind limbs were observed at 4 weeks after surgery, but coordinated movements were not observed by the end of the 12-week experiment.
PNAS, 2013 • March 5, 2013
This study used a transgenic mouse model to visualize and quantify spontaneously regenerated myelin after spinal cord injury, distinguishing it from pre-existing myelin. The research challenges the as...
KEY FINDING: OL-regenerated sheaths elongated progressively over 6 mo to approach control values.
Neurotherapeutics, 2013 • February 26, 2013
This study investigates the potential of combined therapy involving surgical re-implantation of avulsed lumbar spinal roots and intraspinal transplantation of mesenchymal stem cells (MSCs) to promote ...
KEY FINDING: Transplantation of MSCs significantly increased the survival of motoneurons after ventral root avulsion, with a 45% survival rate in MSC-treated animals compared to 28% in vehicle-injected rats.
Exp Neurol, 2013 • September 1, 2013
This study investigates the effects of structurally diverse aggrecan variants on sensory neuron growth cones and filopodia in vitro, modeling their first contact with glial scar CSPGs following spinal...
KEY FINDING: Mutant CHO-745 aggrecan (lacking chondroitin sulfate chains) permitted extensive growth across the PG stripe.
BioMed Research International, 2013 • January 1, 2013
This review comprehensively covers publications in the field of cell transplantation for spinal cord injury (SCI) from recent years, focusing on commonly utilized cell lineages. Specific areas covered...
KEY FINDING: ESC/iPSC-derived cells can promote tissue sparing, neuronal regeneration, axonal regeneration/remyelination, sensory function, and motor function improvement in SCI models.
Neuroscience, 2013 • June 25, 2013
This study investigates the role of ephrin B2, an inhibitory axonal guidance molecule, in the failure of axonal regeneration following spinal cord injury (SCI). Using a conditional knockout mouse mode...
KEY FINDING: Deletion of ephrin B2 in astrocytes reduced astrogliosis and accelerated motor function recovery after spinal cord injury in mice.
PLoS ONE, 2013 • March 8, 2013
The study aimed to determine if ARSB, a mammalian enzyme, could improve locomotor function after spinal cord injury in mice, similar to ChaseABC but with potentially better stability and immunogenicit...
KEY FINDING: ARSB is more thermostable than ChaseABC at physiological temperature and acidic pH levels relevant to injured tissue.