Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 121-130 of 7,812 results
PLoS ONE, 2012 • December 7, 2012
This study used genome-scale transcriptional profiling to identify distinct age-dependent expression profiles in rat sensorimotor cortex during acute, subacute and chronic phases of spinal cord injury...
KEY FINDING: Aging significantly alters the cortical transcriptomes triggered by SCI, with little overlap in lesion-regulated genes between young and old animals.
The Journal of Neuroscience, 2012 • December 12, 2012
This study demonstrates that miR-21 expression increases in astrocytes following spinal cord injury (SCI) and plays a crucial role in regulating astrocytic hypertrophy and glial scar formation. Overex...
KEY FINDING: miR-21 expression increases in astrocytes adjacent to the lesion site following spinal cord injury (SCI).
JOURNAL OF NEUROTRAUMA, 2013 • February 1, 2013
This study provides a comprehensive quantitative description of motor deficits and compensations from the acute to the late chronic phase after C6 spinal cord hemisection. Permanent impairments were d...
KEY FINDING: A dramatic (50%), immediate and permanent loss of extensor force occurred in the forelimb but not in the hind limb of the injured side.
Korean J Physiol Pharmacol, 2012 • December 1, 2012
This study investigates the therapeutic potential of human mesenchymal stem cells (hMSCs) and a polymer scaffold in promoting functional recovery after spinal cord hemisection in rats. The researchers...
KEY FINDING: Functional recovery was significantly improved in the polymer with hMSC-transplanted group as compared with control at five weeks after transplantation.
PLoS ONE, 2012 • December 21, 2012
This study investigates the role of contactin-2 in spinal cord regeneration in adult zebrafish, finding that its expression is upregulated after injury. Using morpholino-mediated knockdown, the resear...
KEY FINDING: Contactin-2 mRNA and protein levels are upregulated along the central canal after spinal cord injury in adult zebrafish, suggesting a role in regeneration.
Int. J. Biol. Sci., 2013 • December 22, 2012
The study investigates the therapeutic potential of transplanting glial-restricted precursor-derived astrocytes (GDAs) expressing the neurotrophin D15A into rats with spinal cord injuries (SCI). The r...
KEY FINDING: Transplantation of D15A-GDAs significantly increased the spared white matter and decreased the injury size compared to control groups.
Biomaterials, 2013 • March 1, 2013
This study investigates the impact of channel density and porosity in PLG bridges on neurite extension in rat and mouse spinal cord injury models. The findings demonstrate that bridges with higher por...
KEY FINDING: Increasing bridge porosity substantially increased the number of axons, correlating with the extent of cell infiltration throughout the bridge.
PLoS ONE, 2012 • December 27, 2012
This study demonstrates that pre-evaluated safe hiPSC-NS/PCs can promote functional recovery after SCI in a common marmoset model without causing tumor formation. The transplanted cells survived and d...
KEY FINDING: Grafted hiPSC-NS/PCs survived and differentiated into neurons, astrocytes, and oligodendrocytes without tumor formation in the injured spinal cord of common marmosets.
STEM CELLS AND DEVELOPMENT, 2013 • May 1, 2013
This study investigates the paracrine interactions between olfactory ensheathing cells (OECs) and mesenchymal stem cells (MSCs) from different sources (adipose tissue, bone marrow, and umbilical cord)...
KEY FINDING: The secretome of OECs positively affects the metabolic activity and proliferation of MSCs, especially ASCs.
Journal of Neuroinflammation, 2013 • January 14, 2013
This study challenges previous in vitro findings by demonstrating that IL-1β exerts detrimental effects on axon plasticity, lesion development, and gliosis after spinal cord injury (SCI) in mice. The ...
KEY FINDING: Local application of recombinant IL-1β worsened the neurological outcome after SCI in mice.