Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 111-120 of 7,812 results
Exp Neurobiol, 2012 • September 1, 2012
Injured primary sensory axons fail to regenerate into the spinal cord, leading to chronic pain and permanent sensory loss. Recent imaging studies that directly monitored axons arriving at the DREZ in ...
KEY FINDING: Injured sensory axons fail to regenerate into the spinal cord due to the DREZ.
Eur J Neurosci, 2012 • December 1, 2012
The study demonstrates that degrading CSPGs promotes midline crossing and reinnervation of denervated target regions by intact CST axons. ChABC treatment resulted in functional recovery of the denerva...
KEY FINDING: ChABC treatment enables robust sprouting of intact CST fibers across the midline to innervate denervated grey matter territory in the brainstem and spinal cord.
Clinics, 2012 • October 1, 2012
This study reviews the current therapeutic approaches for spinal cord injury (SCI), highlighting the primary and secondary mechanisms of damage. The review discusses corrective surgery, physical, biol...
KEY FINDING: Surgical techniques like decompression and stabilization are used to prevent further injury, but their effectiveness in restoring function remains controversial.
CNS Neuroscience & Therapeutics, 2013 • January 1, 2013
This study investigates the mechanism of endoplasmic reticulum (ER) stress–induced apoptosis and the protective action of basic fibroblast growth factor (bFGF) in spinal cord injury (SCI). bFGF admini...
KEY FINDING: ER stress-induced apoptosis is involved in the early stages of spinal cord injury in rats, indicated by increased levels of GRP78, CHOP, and caspase-12.
Nat Med, 2012 • November 1, 2012
Angiogenesis is a key feature of central nervous system injury. A neovessel-derived signal mediated by prostacyclin triggers axonal sprouting and functional recovery in a mouse model of inflammatory s...
KEY FINDING: Neovessels are formed in perilesional tissue in both inflammatory and traumatic spinal cord injury3,4. In this issue of Nature Medicine, Muramatsu et al.5 use a highly targeted inflammatory injury to the thoracic spinal cord that damages descending corticospinal tract (CST) projections from the brain to model some aspects of human multiple sclerosis.
The Journal of Neuroscience, 2012 • November 7, 2012
Lu et al. (2012) provide an important contribution to the field of neuroscience in demonstrating axonal regeneration following partial and complete cord transection. Perhaps surprisingly, this regener...
KEY FINDING: A combinatorial treatment strategy promoted axonal regeneration in both hemisection and full transection models.
Brain Behav Evol, 2012 • January 1, 2012
The present study examined proliferation and survival of cells following complete spinal cord transection rather than tail amputation in the weakly electric fish Apteronotus leptorhynchus. Spinal tran...
KEY FINDING: Spinal cord transection significantly increased the density of BrdU+ cells along the entire length of the spinal cord at 1 day post transection (dpt), and most newly generated cells survived up to 14 dpt.
Biomaterials, 2013 • February 1, 2013
This study assessed the potential of bioengineered scaffolds to support and guide axonal growth in a severe spinal cord injury model involving complete spinal cord transection in adult rats. The findi...
KEY FINDING: Templated agarose scaffolds support motor axon regeneration into a severe spinal cord injury model.
STEM CELLS TRANSLATIONAL MEDICINE, 2012 • October 10, 2012
This review examines the potential of SDF-1 and its receptors to enhance stem cell function in spinal cord repair, highlighting its role in recruiting stem cells, promoting cell survival and maturatio...
KEY FINDING: SDF-1 is crucial for recruiting transplanted stem cells and endogenous progenitor cells to promote functional recovery after spinal cord injury.
Int. J. Mol. Sci., 2012 • October 19, 2012
This study examined changes in GDNF protein and mRNA expression levels in the spinal cord after hemi-transection in rats. The key finding was that GDNF protein accumulated in the rostral part of the i...
KEY FINDING: GDNF protein levels increase rapidly in the rostral part of the spinal cord after hemi-transection.