Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 101-110 of 7,812 results
JOURNAL OF NEUROTRAUMA, 2013 • February 1, 2013
This study investigated the effects of sialidase and chondroitinase ABC (ChABC), alone and in combination, on recovery from spinal cord contusion injury in rats. The enzymes were infused for 2 weeks t...
KEY FINDING: Sialidase treatment alone resulted in significantly increased hindlimb motor function, evidenced by higher BBB scores and fewer stepping errors.
The Journal of Neuroscience, 2012 • September 12, 2012
The study demonstrates that selective CST injury induces maladaptive afferent fiber plasticity remote from the lesion, suggesting a novel structural reaction of proprioceptive afferents to the loss of...
KEY FINDING: Selective CST injury induces proprioceptive afferent plasticity in the spinal cord, leading to sprouting of afferent fibers into denervated gray matter regions.
PLoS ONE, 2012 • August 28, 2012
This study investigates the efficacy of acellular sciatic nerve (ASN) combined with brain-derived neurotrophic factor (BDNF) in repairing spinal cord injury (SCI) in adult rats. The results suggest th...
KEY FINDING: Transplantation of ASN-BDNF shows promise for neuron regeneration.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2011 • June 6, 2011
The study investigated the neuroprotective effects of erythropoietin (EPO) on spinal cord injury (SCI) in rats, focusing on the role of platelet-derived growth factor (PDGF)-B. Results showed that EPO...
KEY FINDING: EPO treatment resulted in a more rapid recovery in SCI rats, as evidenced by higher BBB scores.
British Journal of Pharmacology, 2013 • February 1, 2013
This study investigates the effects of denosomin on functional recovery in SCI mice and elucidates the mechanism through which denosomin induces axonal growth in the injured spinal cord. The key findi...
KEY FINDING: Denosomin improves motor dysfunction and axonal growth, especially in 5-HT-positive tracts across the scar, and increases astrocyte density in SCI mice.
Cell, 2012 • September 14, 2012
Neural stem cells (NSCs) expressing GFP were embedded into fibrin matrices containing growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells differentiated into multi...
KEY FINDING: Neural stem cells, when grafted into sites of complete spinal cord transection, differentiated into neurons and extended axons over remarkably long distances (up to 25 mm) in both rostral and caudal directions.
The Journal of Neuroscience, 2012 • September 19, 2012
The study examined the necessity of continuous NT-3 delivery for sustaining regenerated sensory axons in injured spinal cords using a tetracycline-regulated lentiviral gene delivery system in rats. Re...
KEY FINDING: Regenerated sensory axons require continuous NT-3 delivery for sustained growth and survival in the injured spinal cord.
Exp Neurol, 2013 • January 1, 2013
The study investigated whether exogenous BDNF could enhance axonal regeneration beyond a ChABC-treated glial interface in a chronic spinal cord injury model using peripheral nerve grafts (PNGs). While...
KEY FINDING: ChABC treatment alone promoted axonal regeneration beyond the graft-host interface.
Glia, 2013 • February 1, 2013
This study investigates the effect of conditional Sox9 ablation on gene expression, glial scarring, and functional recovery after SCI. Sox9 conditional knock-out improved hind limb motor function in m...
KEY FINDING: Conditional Sox9 knock-out mice expressed reduced levels of CSPG biosynthetic enzymes, CSPG core proteins, collagens, and Gfap in the injured spinal cord.
PLoS ONE, 2012 • September 25, 2012
This study investigates the potential of neural stem cells (NSCs) engineered to secrete a trimerized form of the L1 cell adhesion molecule to promote spinal cord regeneration in mice. The researchers ...
KEY FINDING: Stem cells expressing trimeric and full-length L1 are more efficient in promoting locomotor recovery compared to stem cells overexpressing only full-length L1 or the parental stem cells.