Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 621-630 of 702 results
Frontiers in Molecular Neuroscience, 2022 • September 7, 2022
This review focuses on the unique advantages of using zebrafish larvae as a model for studying spinal cord regeneration, emphasizing their optical transparency, simple anatomy, and complex locomotor b...
KEY FINDING: Spinal cord regeneration in zebrafish larvae is distinct from development, with injury-dependent responses such as immune cell infiltration and glial bridge formation.
Nucleic Acids Research, 2023 • November 1, 2022
The Human Universal Single Cell Hub (HUSCH) is introduced as a curated database integrating single-cell transcriptomic profiles from nearly 3 million cells across 45 human tissues. HUSCH uniformly pro...
KEY FINDING: HUSCH integrates single-cell transcriptomic profiles of nearly 3 million cells from 185 high-quality human scRNA-seq datasets across 45 different tissues.
Acta Cir Bras, 2022 • August 1, 2022
This study investigated the impact of aerobic treadmill exercises on nerve regeneration following sciatic nerve injury and repair with a nerve graft in rats. The rats were divided into four groups: SH...
KEY FINDING: Functional analysis (SFI) did not show a statistical difference between the group grafted with (–50.94) and without exercise (-65.79) after 90 days.
Frontiers in Molecular Neuroscience, 2022 • October 31, 2022
This bibliometric study analyzes publications on gene expression in spinal cord injury (SCI) from 2000 to 2022, identifying key trends and research hotspots in the field. The study highlights the most...
KEY FINDING: China and the United States are the most productive countries in gene expression research related to SCI, but the United States has a higher average article citation rate, suggesting a stronger influence.
Trials, 2022 • November 3, 2022
This study protocol outlines a comprehensive cohort trial comparing full-endoscopic and microsurgical techniques for lumbar disc herniation treatment. The study includes a randomized and a non-randomi...
KEY FINDING: The study aims to compare the results of lumbar discectomies using the full-endoscopic technique via the interlaminar and trans-foraminal access with those of the conventional microsurgical technique, particularly with regard to iatrogenic muscle trauma and patient-related outcome measures.
Cells, 2022 • November 22, 2022
This study compared the time course of neuronal, glial, and sensorimotor recovery in A/J and C57BL/6J mice following sciatic nerve crush. A/J mice showed higher expression of MHC-I, Iba-1 (microglial ...
KEY FINDING: MHC-I upregulation peaks at 7 days postinjury in both C57BL/6J and A/J mice, but is significantly higher in the A/J strain.
Journal of Medical Case Reports, 2022 • November 30, 2022
This case report describes an 81-year-old man who developed unilateral delayed post-hypoxic leukoencephalopathy (DPHL) following a dissection-related occlusion of the left carotid artery. The patient ...
KEY FINDING: Clinical symptoms suggestive of delayed post-hypoxic leukoencephalopathy (DPHL) can be observed in very rare cases following successful revascularization therapy in large vessel occlusions, causing acute ischemic stroke.
Bioengineering, 2023 • March 7, 2023
The study established a metaphyseal femoral non-union model in osteoporotic rats by comparing a piezoelectric saw versus a manual Gigli wire saw for osteotomy creation. Osteoporotic phenotype was indu...
KEY FINDING: Ovariectomized rats showed a significant reduction in cancellous and total bone mineral density compared to control rats, confirming the development of osteoporosis.
Scientific Reports, 2023 • March 27, 2023
This study comprehensively evaluates pharmacological management practices in acute spinal cord injury using data from a clinical trial and an observational study. The analysis revealed a high rate of ...
KEY FINDING: A wide range of medications (775 unique medications) are administered within the first two months after spinal cord injury.
Neurospine, 2023 • January 1, 2023
This meta-analysis examined the safety and accuracy of robot-assisted (RA) techniques for cervical screw placement in spine surgery. It included one RCT, three comparative cohort studies, and three ca...
KEY FINDING: The meta-analysis indicated that robot-assisted techniques achieved an 88.0% rate of optimal cervical screw placement accuracy.