Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 141-150 of 702 results
PLoS ONE, 2017 • April 17, 2017
The study aimed to develop a safe surgical method for removing intramedullary hemorrhagic necrosis (IHN) after spinal cord contusion in rats to create a cavity for future therapeutic implants. A small...
KEY FINDING: Small surgical approach to debridement (SSAD) effectively removed hemorrhagic necrosis after acute cord contusion in rats.
International Journal of Immunopathology and Pharmacology, 2018 • August 28, 2018
Glial scar formation is a complex response to injury in the central nervous system, involving astrocytes, immune cells, and extracellular matrix deposition, which can both inhibit and promote neural r...
KEY FINDING: Glial scar formation involves the activation of resident astrocytes, which surround the lesion core and wall off intact neurons in neurological damages.
Anat Rec (Hoboken), 2012 • October 1, 2012
This study provides a histological comparison of the mature regenerated and original tail of the lizard Anolis carolinensis. The regenerated tail has a cartilage skeleton enclosing a spinal cord but l...
KEY FINDING: The regenerated tail has a cartilage tube with foramina, enclosing a spinal cord with an ependymal core, but no regeneration of dorsal root ganglia or peripheral nerves.
Histochemistry and Cell Biology, 2021 • May 8, 2021
This study characterized scleral cells and examined their response to inflammatory stimulation using an ex vivo model. The research demonstrated that scleral cells express tendon-associated markers an...
KEY FINDING: Scleral cells express tendon-associated markers such as scleraxis, tenomodulin and mohawk.
Signal Transduction and Targeted Therapy, 2022 • January 1, 2022
This article is a correction notice for a paper that investigated cellular and molecular changes in the spinal cord after injury. The corrections address errors in figure presentations, specifically t...
KEY FINDING: The original article mistakenly switched “4h” and “1d” UMAP plots in Fig. 2g.
Journal of Neuroinflammation, 2022 • January 1, 2022
This study investigates the role of the PDGFRβ pathway in fibrotic scar formation after spinal cord injury (SCI) and the therapeutic potential of SU16f, a PDGFRβ inhibitor. The results demonstrate tha...
KEY FINDING: PDGFB is mainly secreted by astrocytes, while PDGFD is mainly secreted by macrophages/microglia and fibroblasts after SCI.
Neurobiol Dis., 2018 • August 1, 2018
This study investigates the role of fibronectin EDA (FnEDA) in fibrotic scarring after spinal cord injury (SCI) using FnEDA-null mice. The research found that eliminating FnEDA reduces chronic fibroti...
KEY FINDING: Eliminating FnEDA did not reduce the acute fibrotic response but markedly diminished chronic fibrotic scarring after SCI.
Nature Neuroscience, 2024 • July 1, 2024
This study identifies that stromal fibroblasts forming the fibrotic scar derive from two populations of perivascular cells after spinal cord injury (SCI) in adult mice of both sexes. The contribution ...
KEY FINDING: Stromal fibroblasts forming fibrotic scars after SCI in mice originate from two distinct perivascular cell populations: pericytes and perivascular fibroblasts.
Cells, 2022 • August 2, 2022
In this review, we discussed fibrotic scar formation in CNS injuries with information covering pathological fibroblasts’ origins and the mechanism of fibroblast activation. We reviewed how a CNS fibrotic ...
KEY FINDING: Meningeal fibroblasts have long been shown to play a role in the fibrotic scar formation in CNS trauma after migrating into the lesion through the torn meninges.
American Journal of Pathology, 2019 • July 1, 2019
This review discusses the role of pericytes in spinal cord injury, focusing on their involvement in scar formation and potential as therapeutic targets. A specific subset of pericytes (Glast+) contrib...
KEY FINDING: A subset of pericytes (Glast+) contributes significantly to fibrotic scar formation after spinal cord injury in mice.