Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 781-790 of 2,298 results
PNAS, 2005 • September 27, 2005
The study investigated the potential of human central nervous system stem cells (hCNS-SCns) to promote recovery in spinal cord-injured mice. The researchers found that hCNS-SCns survived, migrated, an...
KEY FINDING: hCNS-SCns survive, engraft, differentiate, and are associated with locomotor improvements after traumatic spinal cord injury in NOD-scid mice.
JOURNAL OF NEUROTRAUMA, 2017 • May 15, 2017
Therapeutic interventions after spinal cord injury (SCI) routinely are designed to address multiple aspects of the primary and/or secondary damage that occurs. Exercise has a demonstrated efficacy for ...
KEY FINDING: Acute and chronically injured propriospinal neurons within the lumbar spinal cord displayed the greatest propensity for enhanced regeneration after exercise, which correlates with the direct sensory input to this region from exercised hindlimb muscles.
PNAS, 2017 • May 9, 2017
The study details a method for differentiating human pluripotent stem cells into V2a interneurons, which are crucial for motor control and are often damaged in spinal cord injuries. The differentiatio...
KEY FINDING: The study successfully differentiated human pluripotent stem cells (hPSCs) into CHX10+ V2a interneurons using a specific combination of signaling molecules.
Neurosci Bull, 2013 • August 1, 2013
This review compares axonal regeneration after spinal cord injury (SCI) in mammals and zebrafish, highlighting the differences in intrinsic and extrinsic factors that contribute to regeneration failur...
KEY FINDING: Mammalian CNS axons do not spontaneously regenerate after a lesion due to extrinsic (lack of growth-promoting molecules and surplus of growth-inhibitory molecules) and intrinsic mechanisms.
Stem Cell Reports, 2017 • May 4, 2017
Transplanted multipotent human central nervous system-derived neural stem cells transplanted at doses ranging from 10,000 (low) to 500,000 (very high) cells differentiated predominantly into the oligo...
KEY FINDING: Increasing the transplant dose of hCNS-SCns resulted in a plateau of engraftment at the highest dose (500,000 cells), suggesting a limit to the SCI niche's capacity.
Cellular and Molecular Neurobiology, 2006 • July 29, 2006
This study investigates the therapeutic potential of human mesenchymal stem cells (hMSCs) for spinal cord injury (SCI) in rats. hMSCs were intravenously injected into rats seven days after SCI, and fu...
KEY FINDING: Transplanted rats showed statistically significant improvement in locomotor function at 21 and 28 days after spinal cord injury compared to the control group.
Phil. Trans. R. Soc. B, 2006 • July 31, 2006
CNS injuries have limited repair capabilities, but functional recovery is observed, which is variable. Neurite growth and new circuit formation require reactivation of developmental mechanisms, suppre...
KEY FINDING: Inactivation of Nogo-A promotes axonal regeneration and improved behavioral recovery after spinal cord injury.
Neural Regeneration Research, 2017 • April 1, 2017
Paralysis following spinal cord injury (SCI) is due to failure of axonal regeneration. It has been suggested that the small GTPase RhoA is an intracellular convergence point for signaling by these ext...
KEY FINDING: RhoA knockdown promotes true axon regeneration through the lesion site after SCI in lampreys.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017 • January 1, 2017
This study investigates the potential of erythropoietin (EPO) to enhance the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) in treating spinal cord injuries (SCI) in rats. The resul...
KEY FINDING: EPO enhances the recruitment of BMSCs to sites of SCI, leading to increased BMSC presence at the injury site.
Cells, 2022 • March 10, 2022
The study aimed to determine whether batch effects related to cell culture materials could influence BMSC gene expression, phenotype, and function, specifically examining the impact of hPL versus FBS ...
KEY FINDING: hPL significantly increased BMSC proliferation, created significantly different gene expression trajectories and distinct surface marker signatures, already after just one passage.