Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 771-780 of 2,298 results
Spinal Cord Series and Cases, 2016 • January 7, 2016
This case report details the recovery of a patient with chronic, complete SCI following olfactory mucosal autograft (OMA) transplantation combined with intensive rehabilitation. The patient showed imp...
KEY FINDING: The patient exhibited voluntary electromyograph (EMG) activity and MEPs at 96 and 144 weeks after transplantation.
Neural Regeneration Research, 2017 • January 1, 2017
Regenerative medicine offers hope for functional recovery in acute-to-subacute SCI, but chronic SCI treatment remains challenging. Combined therapies, especially those including rehabilitation, are ga...
KEY FINDING: Treadmill training combined with neural stem/progenitor cell (NS/PC) transplantation promotes functional recovery in chronic SCI, showing both additive and synergistic effects.
Scientific Reports, 2017 • March 6, 2017
This study investigated the therapeutic effects of a NeuroRegen scaffold functionalized with human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in a canine chronic spinal cord injury (SCI)...
KEY FINDING: Functionalized NeuroRegen scaffold implantation promoted both locomotor recovery and endogenous neurogenesis in the lesion area.
International Journal of Molecular Sciences, 2017 • February 27, 2017
This study investigated the effects of transplanting embryonic spinal cord-derived cells into injured peripheral nerves to prevent muscle atrophy. Both fetal cells (P0) and neural progenitor cells (P2...
KEY FINDING: Both fetal spinal cord cells (P0) and neural progenitor cells (P2) were able to survive in the injured peripheral nerve environment.
Stem Cells International, 2017 • February 16, 2017
This review discusses restorative approaches for spinal cord injuries (SCIs) using cell therapies, specifically olfactory ensheathing cells (OECs) and mesenchymal stem cells (MSCs). These cells have s...
KEY FINDING: Olfactory ensheathing cells (OECs) express neurotrophic factors that are important for axon extension and guidance. They can migrate from the peripheral to the central nervous system, enhancing axonal extension after injury.
Front. Mol. Neurosci., 2019 • April 12, 2019
This review discusses the potential of bioscaffolds and extracellular vesicles (EVs) in treating spinal cord injury (SCI). Bioscaffolds can bridge lesion gaps and facilitate axonal regeneration, while...
KEY FINDING: Bioscaffolds can ameliorate the spinal cord microenvironment and direct cell behaviors such as migration, proliferation and differentiation.
The Journal of Neuroscience, 2017 • September 20, 2017
This study demonstrates that the timing of hCNS-SCns transplantation post-SCI affects the localization and differentiation of donor cells. Acute transplantation (0 dpi) resulted in astroglial differen...
KEY FINDING: Acute transplantation of hCNS-SCns resulted in localized astroglial differentiation of donor cells near the lesion epicenter and failure to produce functional improvement.
Regenerative Therapy, 2024 • July 1, 2024
This review explores the potential of adipose-derived stem cell (ADSC) therapy for spinal cord injury (SCI), focusing on its ability to improve function, progress in preclinical and early clinical tri...
KEY FINDING: Preclinical studies suggest ADSC transplantation promotes functional recovery, reduces cavity formation, and enhances nerve regrowth and myelin repair in SCI models.
Annu Rev Med, 2004 • January 1, 2004
The prospects for successful clinical trials of neuroprotective and neurorestorative interventions for patients with acute and chronic myelopathies depend on preclinical animal models of injury and re...
KEY FINDING: Neurotrophic factors, such as BDNF, can reverse atrophy of rubrospinal neurons and promote spinal axon regeneration, even when administered long after SCI.
The Journal of Neuroscience, 2005 • February 2, 2005
The study investigates a combinatory strategy to promote axonal regeneration and functional recovery after complete spinal cord transection in adult rats. The treatment involved reducing inhibitory cu...
KEY FINDING: The combination of SC bridge, olfactory ensheathing glia, and chondroitinase ABC provided significant benefit compared with grafts only or the untreated group.