Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 761-770 of 2,298 results
Neurol Med Chir (Tokyo), 2016 • April 6, 2016
This pilot study investigated the feasibility and safety of olfactory mucosa autograft (OMA) for treating chronic complete spinal cord injury. The procedure involves transplanting the patient's own ol...
KEY FINDING: The olfactory mucosa autograft (OMA) procedure was found to be safe, with no serious adverse events reported in any of the eight patients.
Stem Cells International, 2016 • January 10, 2016
The study aimed to assess the effect of L. angustifolia extract on the outcome of transplantation of HUMSCs from Wharton’s jelly after contusive SCI in Wistar rats. Behavioral tests showed that HUMSC ...
KEY FINDING: HUMSC transplantation alone improved locomotor function compared to the SCI control group.
Advanced Biomedical Research, 2016 • January 1, 2016
This study investigated the safety and efficacy of co-infusing autologous adipose tissue-derived mesenchymal stem cells (N-Ad-MSC) and hematopoietic stem cells (HSCs) in patients with post-traumatic p...
KEY FINDING: The co-infusion of N-Ad-MSC and HSC in CSF is a safe and viable therapeutic approach for SCIs.
Frontiers in Cell and Developmental Biology, 2017 • January 19, 2017
This review discusses the potential of induced pluripotent stem cells (iPSCs) for treating traumatic spinal cord injury (SCI). Cell-based therapies offer an exciting strategy to address this pressing ...
KEY FINDING: iPSCs can differentiate into neural precursor cells, neural crest cells, neurons, oligodendrocytes, astrocytes, and even mesenchymal stromal cells, offering diverse therapeutic potential for SCI.
Journal of Craniovertebral Junction and Spine, 2016 • January 1, 2016
Stem cell therapy is being investigated as a potential treatment for spinal cord injury (SCI), which currently lacks effective primary treatment options. Various types of stem cells, including mesench...
KEY FINDING: Mesenchymal stem cells (MSCs), particularly bone marrow stromal cells (BMSCs), have shown improved functional recovery in rodent models of SCI and some clinical trials.
PLoS Biology, 2016 • May 31, 2016
This meta-analysis examined the efficacy of olfactory ensheathing cell (OEC) transplantation in experimental spinal cord injury (SCI). The study found a significant overall effect of OEC transplantati...
KEY FINDING: OEC transplantation improved locomotor recovery by 20.3% in experiments reporting BBB measures.
Neural Regeneration Research, 2016 • May 1, 2016
This study investigates the effects of repetitive magnetic stimulation (rMS) on nerve regeneration after spinal cord injury (SCI) in rats. The study found that rMS improved the microenvironment of neu...
KEY FINDING: Repetitive magnetic stimulation reduced the number of apoptotic cells in the injured spinal cord.
Stem Cell Reports, 2017 • February 14, 2017
This study evaluated the efficacy of human neural stem cells (HuCNS-SCs) in a mouse model of cervical spinal cord injury (SCI), comparing a research cell line (RCL) and a clinical cell line (CCL) inte...
KEY FINDING: The research cell line (HuCNS-SC RCL) showed some improvement in locomotor function when transplanted 9 days post-injury (DPI) in mice with cervical SCI.
Neural Regeneration Research, 2016 • July 1, 2016
Transplantation of somatic cells like BMSCs, BMNCs, and CPECs enhances axon regeneration and locomotor improvements, despite their short-term survival and lack of integration into the host spinal cord...
KEY FINDING: BMSCs, BMNCs, and CPECs enhance axon regeneration and locomotor function without long-term survival in the host spinal cord, suggesting the release of trophic factors.
Stem Cell Reports, 2017 • February 16, 2017
This study investigates the efficacy of neural stem cell (NSC) transplantation in aged mice with spinal cord injury (SCI). It addresses the increasing number of elderly patients with SCI and the limit...
KEY FINDING: Aged mice exhibited less functional recovery from SCI than young mice, with higher mortality rates and larger damaged areas in the spinal cord.