Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 651-660 of 2,298 results
eLife, 2021 • May 4, 2021
The study investigates dorsal root (DR) regeneration after injury, focusing on the roles of myelin inhibitors and chondroitin sulfate proteoglycans (CSPGs). It finds that co-eliminating myelin inhibit...
KEY FINDING: Genetic deletion of myelin inhibitors (Nogo, MAG, OMgp) alone elicits little regeneration across the dorsal root entry zone (DREZ).
Cells, 2021 • May 12, 2021
This study demonstrates that increasing the yield of olfactory ensheathing cells (OECs) from mucosal cultures can promote axonal regeneration and functional recovery in a rat dorsal root injury model....
KEY FINDING: A modified culture protocol increased the yield of mucosal OECs to approximately 20%, a fourfold increase compared to previous methods.
Open Veterinary Journal, 2021 • June 4, 2021
This study evaluates the use of autologous bone marrow-derived stromal cells in platelet-rich plasma for treating chronic spinal cord injuries in dogs and cats via a one-time combined intrathecal/intr...
KEY FINDING: The combined intrathecal/intravenous injection of bone marrow stromal cells is a safe and promising procedure for treating chronic spinal cord injuries in companion animals.
Journal of the American Heart Association, 2022 • January 1, 2022
This study investigates the potential of shock wave therapy (SWT) to mitigate spinal cord ischemia (SCI) following aortic surgery. The research includes in vitro experiments on human neurons, in vivo ...
KEY FINDING: SWT reduces reactive oxygen species and apoptosis in human neurons subjected to ischemic injury.
Biomedicines, 2022 • October 13, 2022
The article reviews current interventions for spinal cord injury (SCI) treatment, focusing on rehabilitation phases and emphasizing a neuroplasticity-based multimodal approach. It highlights the integ...
KEY FINDING: Biomolecular approaches alone have modest outcomes in SCI treatment.
North American Spine Society Journal, 2023 • January 1, 2023
Here we reviewed the overview of regenerative medicine of SCI. At the same time, the search for effective treatments for chronic SCI is proceeding gradually, combining hiPSC-NS/PC transplantation with ...
KEY FINDING: hiPSC-NS/PC transplantation into subacute injured spinal cords has been repeatedly demonstrated to improve locomotor function.
Biomedicines, 2022 • December 6, 2022
Spinal cord injury (SCI) presents a significant unmet clinical need. Olfactory ensheathing cell (OEC) transplantation is a promising therapeutic approach for SCI repair, but variability in clinical ou...
KEY FINDING: OEC transplantation shows promise for SCI repair due to their unique properties in supporting nerve regeneration and modulating the inflammatory response.
Cells, 2023 • December 28, 2022
This review explores the molecular mechanisms of action of multipotent stem cells (MSCs, NSCs, and HSCs) and their clinical efficacy in treating SCI. It discusses the pathogenesis of SCI, optimal stem...
KEY FINDING: MSCs reach the lesion site through the chemotactic mechanism known as a homing effect, which is important for therapy effectiveness.
Int. J. Mol. Sci., 2023 • January 3, 2023
Spinal cord injury (SCI) leads to reduced motor, sensory, and autonomic functions, with an increasing incidence worldwide. Regenerative biomaterials offer a promising treatment option by using tissue ...
KEY FINDING: Hyaluronic acid (HA) reduces glial scar formation and improves the therapeutic effect of SCI by transporting drugs and stem cells to the injury area, enhancing the survival and differentiation of neural stem cells.
Stem Cells Translational Medicine, 2023 • January 17, 2023
This study demonstrates the efficacy of the combination therapy of human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) transplantation and rehabilitative training i...
KEY FINDING: Rehabilitative training promoted the survival rate and neuronal differentiation of transplanted hiPSC-NS/PCs in the chronic SCI model.