Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 641-650 of 2,298 results
Cells, 2020 • November 6, 2020
The study aimed to identify the origins of early regenerating axons in lampreys after spinal cord injury, as these axons contribute to early functional recovery. BABB clearing significantly improved t...
KEY FINDING: Over 50% of the early regenerating axons belonged to small neurons in the brainstem, specifically in the posterior and middle rhombencephalic reticular nuclei (PRRN and MRRN).
Frontiers in Cellular Neuroscience, 2020 • October 14, 2020
Neural stimulation modulates the depolarization of neurons, thereby triggering activity-associated mechanisms of neuronal plasticity. New research has uncovered genetic mechanisms that govern the expr...
KEY FINDING: Patterns of depolarization in neurons are shown to be important mediators of genetic expression patterns and molecular responses.
Experimental & Molecular Medicine, 2020 • December 14, 2020
This study investigates the potential of Wnt5a to enhance neural stem cell (NSC) transplantation for spinal cord injury (SCI) repair. The research demonstrates that Wnt5a promotes NSC differentiation ...
KEY FINDING: Wnt5a and miRNA200b-3p promote NSC differentiation into neurons, with Wnt5a upregulating miRNA200b-3p expression through the MAPK/JNK pathway.
BioMed Research International, 2020 • December 7, 2020
This study investigates the combined effect of ultrashort wave (USW) therapy and human umbilical cord mesenchymal stem cell (HUC-MSC) transplantation on spinal cord injury (SCI) in rats. The combinati...
KEY FINDING: The combination of USW and HUC-MSCs significantly improved motor function in SCI rats, with USW playing a more prominent role.
Stem Cell Research & Therapy, 2021 • January 7, 2021
This review discusses the potential of mesenchymal stem cell (MSC)-derived exosomes as a therapeutic strategy for spinal cord injury (SCI), highlighting their advantages over traditional MSC therapy. ...
KEY FINDING: Exosomes derived from MSCs have anti-inflammatory effects, reducing pro-inflammatory cytokines and promoting an anti-inflammatory environment conducive to functional recovery after SCI.
Cell Transplantation, 2021 • January 4, 2021
Stem cells have neuroregenerative and neuroprotective effects in SCI cell therapy. Cell-based therapies in SCI have different mechanisms in functional recovery, such as immunomodulation, cell replacem...
KEY FINDING: BM-MSC therapy is beneficial for SCI recovery by improving the microenvironment of the injury site, enhancing nutritional support, modulating the inflammatory response, and alleviating BSCB leakage.
Exp Neurol, 2021 • May 1, 2021
The study confirms that KLF6 can enhance axon sprouting in the corticospinal tract but only when there's an injury. This sprouting occurs noticeably within four weeks of KLF6 treatment. Despite the in...
KEY FINDING: KLF6's pro-growth effects on corticospinal tract axons require an injury stimulus, as KLF6 expression alone did not trigger sprouting.
MOLECULAR MEDICINE REPORTS, 2021 • January 7, 2021
The study aimed to compare the therapeutic effects of monotherapy (TMS, BMSCs, or RafI) and combination therapy (TMS+BMSCs or TMS+RafI) on spinal cord injury (SCI) in rats. The results demonstrated th...
KEY FINDING: Monotherapy (TMS, BMSCs, or RafI) significantly enhanced locomotor functional recovery in SCI model rats, as evidenced by higher BBB scores, and slightly alleviated histopathological lesions of the spinal cord.
Stem Cell Research & Therapy, 2021 • January 31, 2021
This study demonstrates that NCSCs delivered at the injury site using a scaffold ameliorate neuropathic pain and enhance locomotion after PNI through inhibiting glial activation as well as ERK and NF-...
KEY FINDING: NCSC-laden nerve scaffolds mitigated SNT-induced neuropathic pain and improved motor function recovery after sciatic nerve repair.
J Transl Med, 2021 • May 7, 2021
This meta-analysis evaluated the efficacy and safety of MSCs in treating SCI, exploring optimal cell sources and transplantation methods. The study found that MSCs transplantation significantly improv...
KEY FINDING: MSCs significantly improved ASIA motor score, sensory score, ASIA grade, and BI compared to rehabilitation.