Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 631-640 of 2,298 results
J Cell Mol Med, 2020 • May 1, 2020
This study demonstrates that polydatin (PD) enhances the neuronal differentiation of bone marrow mesenchymal stem cells (BMSCs) both in vitro and in vivo, particularly promoting their differentiation ...
KEY FINDING: PD markedly facilitated BMSC differentiation into neuron-like cells by activating the Nrf2 pathway and increased the expression of neuronal markers in the transplanted BMSCs at the injured spinal cord sites.
Cells, 2020 • May 25, 2020
This study aimed to examine changes in neuronal DNA methylation status after SCI and to determine whether modulation of DNA methylation with ascorbic acid can enhance neuronal regeneration or function...
KEY FINDING: SCI induces alteration of 5mC and 5hmC Levels in the Brain Motor Cortex. The intensity of 5hmC was significantly higher in the SCI group than in the control group at 1 day (acute stage) and 1 week after injury.
Cell Death & Disease, 2020 • June 1, 2020
This review summarizes recent progress in biological and engineering strategies for reconstructing neural circuits and promoting functional recovery after SCI, emphasizing current challenges and futur...
KEY FINDING: Gene regulation of neural regeneration, cell or cell-derived exosomes and growth factors transplantation, repair of biomaterials, and neural signal stimulation lead to axonal regeneration and neural circuit reconstruction.
JCI Insight, 2020 • August 6, 2020
The present study provides evidence that SWT holds significant potential as therapeutic approach for the treatment of chronic SCI and presents mechanistic insight into its mode of regeneration. At lea...
KEY FINDING: SWT markedly improved locomotor function in WT animals in comparison with untreated control animals, whereas SWT had no effect in Tlr3-deficient mice.
Neurotherapeutics, 2020 • August 27, 2020
This study investigates the potential of repetitive trans-spinal magnetic stimulation (rTSMS) as a noninvasive treatment for spinal cord injury (SCI) in mice, focusing on tissue repair and functional ...
KEY FINDING: rTSMS modulates the lesion scar by decreasing fibrosis and inflammation, suggesting it promotes a more permissive environment for regeneration.
Cell Transplantation, 2020 • January 1, 2020
This study investigated the safety and efficacy of using NeuroRegen scaffolds combined with autologous bone marrow mononuclear cells (BMMCs) to treat acute complete spinal cord injury (SCI). Seven pat...
KEY FINDING: Implantation of NeuroRegen scaffolds combined with BMMCs appeared safe, with no adverse events related to the scaffold or stem cell implantation observed during the 3-year follow-up.
eLife, 2020 • September 7, 2020
This study demonstrates evidence for a receptor-mediated signaling role for complement C1q in the CNS, modulating NSC migration, proliferation, and lineage commitment. The study defines and validates ...
KEY FINDING: C1q activates specific intracellular signaling pathways in NSC to modulate NSC behavior.
J Cell Mol Med, 2020 • January 1, 2020
This study aimed to investigate the role of miR-30b in promoting sensory function recovery after spinal cord injury (SCI) by enhancing primary sensory neuron (PSN) axon growth. The results demonstrate...
KEY FINDING: MiR-30b promotes primary sensory neuron axon growth in vitro by targeting and degrading sema3A mRNA.
Neural Regeneration Research, 2021 • March 1, 2021
Cell transplantation holds promise for treating spinal cord injury (SCI) due to the inadequacies of current treatments. Stem cells, macrophages, and Schwann cells offer potential for nerve regeneratio...
KEY FINDING: Neural stem cell (NSC) transplantation has shown improvements in motor and sensory function in some patients with thoracic SCI, suggesting the potential of allogeneic NSCs.
Journal of Cerebral Blood Flow & Metabolism, 2021 • February 1, 2021
The review discusses the potential of targeting axon guidance molecules, especially Wnts, to promote neural circuit repair after spinal cord injury. It highlights that Wnt signaling inhibits axon rege...
KEY FINDING: Wnt signaling, particularly the Wnt-Ryk pathway, inhibits axon regeneration after spinal cord injury, causing corticospinal tract axon retraction.