NeuroRegen Scaffolds Combined with Autologous Bone Marrow Mononuclear Cells for the Repair of Acute Complete Spinal Cord Injury: A 3-Year Clinical Study

This study explores a new treatment for acute complete spinal cord injury (SCI) using NeuroRegen scaffolds combined with the patient's own bone marrow cells. The researchers surgically implanted these scaffolds, loaded with bone marrow mononuclear cells (BMMCs), into the damaged spinal cord area after cleaning the necrotic tissue. Over a 3-year follow-up, the treatment appeared safe, with some patients showing improvements in sensory and autonomic functions, though motor function recovery was not observed.

• 1
  Implantation of NeuroRegen scaffolds combined with BMMCs appeared safe, with no adverse events related to the scaffold or stem cell implantation observed during the 3-year follow-up.
• 2
  Some patients experienced partial improvements in shallow sensory and autonomic nervous functions, such as defecation sensation, physiological erection and enhanced sweating.
• 3
  MRI scans suggested that the NeuroRegen scaffold implantation supported the continuity of the injured spinal cord after the treatment.