Experimental study of cBMMSC based on nanosilver hydrogel nerve conduit for repairing spinal cord injury

This study explores a new way to treat spinal cord injuries using stem cells from bone marrow combined with a special material called nanosilver hydrogel. The goal is to see if this combination can help repair damaged spinal cords in rats. Researchers transplanted cranial bone marrow mesenchymal stem cells (cBMMSC) into nanosilver hydrogel nerve conduits and then placed them into the injured spinal cords of rats. They compared this to a control group that received the hydrogel but without the stem cells. The study looked at various factors, such as the growth of new nerve cells, the length of nerve fibers, and the rats' ability to move, to determine how well the treatment worked. The results suggest the treatment helps repair spinal cord injuries in rats.

• 1
  cBMMSC transplantation based on nanosilver hydrogel nerve conduit was effective in repairing spinal cord injury, promoting neuronal and axonal regeneration, and restoring neuromotor and electrophysiological functions.
• 2
  The NSE content of MAB1281-positive cells in the experimental group was significantly higher than that of the control group.
• 3
  The number of BrdU-positive cells and axon length were significantly greater than that of the control group.