Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 511-520 of 2,298 results
Neuropsychopharmacology Reviews, 2014 • January 1, 2014
The central nervous system's limited regenerative capacity necessitates innovative strategies for tissue and functional repair. Biomaterials, particularly hydrogels, are being investigated as cell- an...
KEY FINDING: Biomaterial hydrogels can enhance cell survival and integration in the CNS by mimicking the extracellular matrix (ECM) and providing physical support.
Front. Cell. Neurosci., 2023 • December 21, 2023
This study examines the additive effects of RhoA knockdown via morpholinos (MOs) and ChABC treatment on promoting axon regeneration and inhibiting apoptotic signaling in lampreys after spinal cord inj...
KEY FINDING: The combination of RhoA MO plus ChABC had the best protective effect on identified reticulospinal (RS) neurons compared to control, ChABC alone, or RhoA MO alone at 4 weeks post-transection.
Front. Rehabil. Sci., 2024 • January 3, 2024
Regenerative rehabilitation is a promising approach for enhancing upper extremity function recovery in individuals with cervical SCIs by combining regenerative medicine and targeted rehabilitation str...
KEY FINDING: Regenerative rehabilitation therapies are needed to circumvent the limitations of current treatment options and promote neurite regeneration and functional recovery following SCI, especially in the chronic phase.
Cells, 2023 • May 25, 2023
This study aimed to evaluate the effectiveness of adipose-derived mesenchymal stromal cells (AD-MSCs) in treating severe spinal cord injury (SCI), focusing on functional recovery, angiogenesis, and ne...
KEY FINDING: AD-MSC transplantation combined with treadmill exercise training significantly improved motor function in severe SCI compared to other groups.
Nature Communications, 2023 • July 12, 2023
This study introduces an advanced MN-MSC patch that enables sustained delivery of MSC-EVs to the injured spinal cord, avoiding direct stem cell invasion. The MN patch, made of biocompatible porous Gel...
KEY FINDING: The porous MN-MSC patch can effectively maintain the survival of MSCs and sustainably release MSC secretome for at least one week.
Neural Regeneration Research, 2023 • December 1, 2023
Axonal regeneration after spinal cord injury (SCI) is hindered by inhibitory molecules, including myelin-associated inhibitors (Nogo-A, MAG, OMgp) and chondroitin sulfate proteoglycans (CSPGs). These ...
KEY FINDING: Myelin-associated inhibitors like Nogo-A, MAG, and OMgp block neurite outgrowth by binding to receptors like NgR1, Pir-B, and others, initiating downstream signaling pathways like RhoA/ROCK, which leads to actin depolymerization and regeneration failure.
Scientific Reports, 2021 • November 4, 2021
The study aimed to enhance the differentiation potential of hEnSCs into MN-like cells and axonal elongation using the signaling molecules sonic hedgehog (SHH) and retinoic acid (RA), and also by provi...
KEY FINDING: The collagen hydrogel containing EpoB microspheres significantly improved the differentiation of hEnSCs into motor neuron-like cells.
Cells, 2021 • November 27, 2021
Research over the last 20 years has explored using pluripotent stem cell (PSC)-derived cells to treat spinal cord injury (SCI) in various animal models. While these studies have increased our understa...
KEY FINDING: ESC-derived cells have shown efficacy in acute SCI models in animals, suggesting potential for human therapies, but require further optimization and safety measures to address tumorigenic risks.
Neural Regeneration Research, 2023 • April 1, 2023
This review summarizes the progress in reprogramming astrocytes into neurons in vivo in animal models of various CNS conditions. The focus is on spinal cord injury, brain injury, Huntington’s disease,...
KEY FINDING: Astrocytes in the mature CNS can be reprogrammed into functional neurons in vivo, offering a potential avenue for nerve regeneration.
Neural Regeneration Research, 2023 • October 10, 2022
The study investigated the effect of double-target NC-MS on rats with incomplete SCI, finding that it improved motor function and promoted recovery of the descending motor pathway. NC-MS treatment att...
KEY FINDING: Double-target NC-MS treatment improved motor function in rats with incomplete SCI, as evidenced by increased BBB scores and inclined-plane angles.