Regenerative Medicine Research

KEY FINDING: Astrocytes play a controversial role in SCI, with some studies suggesting they create glial scars that inhibit axon regeneration, while others show they can be reprogrammed into neurons to treat SCI.

KEY FINDING: HNSC-secretome treatment significantly decreased F2-Isoprostane levels, indicating antioxidant activity.

KEY FINDING: AMUC injections significantly reduced pain in patients with spinal disorders, with pain scores decreasing as early as two weeks post-injection.

KEY FINDING: Hypoxia-related preconditioning, using either low oxygen or pharmacological agents, did not enhance the survival of Schwann cells transplanted into the injured spinal cord.

KEY FINDING: EV treatment resulted in a greater density of task-related cfos+ pyramidal neurons in the deep layers of the perilesional primary motor cortex (periM1).

KEY FINDING: NPC transplantation can promote functional recovery after SCI through multiple mechanisms, including reconstruction of neuronal circuits, remyelination of axons, and neuroprotection via trophic factors.

KEY FINDING: Vascular repair is critical for proper perfusion pressure and the effective delivery of drugs or cells to the damaged spinal cord tissue.

KEY FINDING: Human iNSCs can be successfully engrafted into the motor cortex of a non-human primate and differentiate into mature neurons.

KEY FINDING: Physiological EF stimulation (100 mV/mm) significantly boosts neuronal differentiation of NSCs in vitro, increasing MAP2 positive cells and neuronal process length.

KEY FINDING: Treatment with HNSC secretomes significantly improved locomotor recovery in rats after spinal cord injury post-laminectomy based on BBB scores.