The Role of Human Neural Stem Cell Secretomes on the Repair of Spinal Cord Injury Post-laminectomy in Rattus norvegicus Through the Analysis of Basso–Beattie–Bresnahan Score Locomotors, Interleukin-10, Matrix Metalloproteinase 9, and Transforming Growth Factor-β

Spinal cord injuries can cause permanent neurological problems. This study looks at how using secretomes from human neural stem cells (HNSC) can help repair spinal cord injuries after a surgery called laminectomy in rats. The researchers measured things like IL-10, MMP9, and TGF-β, which are signs of how well the nerves are recovering, along with how well the rats could move using a scoring system called BBB. The study found that using HNSC secretomes improved how well the rats could move, lowered MMP9 levels, and raised IL-10 and TGF-β levels. This suggests that secretomes can help fix some of the damage from spinal cord injuries.

• 1
  Treatment with HNSC secretomes significantly improved locomotor recovery in rats after spinal cord injury post-laminectomy based on BBB scores.
• 2
  HNSC secretome treatment decreased MMP9 levels in the rats with spinal cord injuries.
• 3
  HNSC secretome treatment increased IL-10 and TGF-β levels in the rats with spinal cord injuries.