Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 291-300 of 2,298 results
Cell Mol Neurobiol, 2015 • December 9, 2014
This study characterized the time course of DCX and GFAP expression in developing rat and porcine spinal cord. In contrast to rats, which display continuing spinal neuronal expression of DCX for the fi...
KEY FINDING: DCX expression in rat spinal cord continues for the first 21 postnatal days, while in newborn piglets, no DCX expression was observed.
Neural Regen Res, 2012 • October 1, 2012
This study demonstrates that EG cells from primary culture release not only NGF and GDNF, but also BDNF, with their respective concentrations reaching 250, 96.4 and 53.8 pg/mL. Although NT-3 release c...
KEY FINDING: Primary enteric glia release nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor into culture medium.
Neural Regen Res, 2012 • October 1, 2012
This study explores the use of autologous platelet-rich plasma (PRP) gel as a seeding matrix for Schwann cell-like cells within a poly(lactic-co-glycolic acid) nerve conduit to repair sciatic nerve de...
KEY FINDING: Platelet-rich plasma group demonstrated a significant increase in the number of regenerating nerve fibers and thickness of the myelin sheath compared with the fibrin group (P < 0.05).
Neural Regen Res, 2012 • October 1, 2012
The study investigates the protective effects of pre-moxibustion at Zusanli (ST36) on gastric mucosal lesions in rats induced by absolute alcohol. It examines the role of heat shock protein 70 (HSP70)...
KEY FINDING: Pre-moxibustion at Zusanli (ST36) can protect the gastric mucosa against lesioning in rats.
World J Orthop, 2015 • January 18, 2015
A number of studies on surgical timing suggest that early surgical intervention is safe and feasible, can improve clinical and neurological outcomes and reduce health care costs, and minimize the seco...
KEY FINDING: Early surgical intervention is safe and feasible, can improve clinical and neurological outcomes and reduce health care costs.
Neural Regeneration Research, 2012 • September 1, 2012
The study examined the differential regulation of p75 and phosphorylated c-Jun (p-c-Jun) in spinal motoneurons of rats at different developmental stages (PN1, PN7, PN14, and adult) following axotomy. ...
KEY FINDING: Intensive phosphorylated c-Jun (p-c-Jun) was induced in axotomized motoneurons in postnatal day (PN)1 and PN7 but not in adults.
Frontiers in Cellular Neuroscience, 2015 • January 13, 2015
This study investigates spinal cord regeneration in Pleurodeles waltlii after complete transection, focusing on the role of neurogenesis and growth factors. It demonstrates that ependymal cells fill t...
KEY FINDING: Nestin expression is prominent in the rostral part of the spinal cord next to the lesion site one week after transection, implying neuronal progenitor migration to replace the missing tissue.
Neural Regeneration Research, 2012 • July 1, 2012
This study aimed to explore the effect of bone marrow mesenchymal stem cell transplantation on the expression of choline acetyltransferase, glutamic acid decarboxylase and synapsins in rats with spina...
KEY FINDING: Intravenously transplanted bone marrow mesenchymal stem cells can migrate to the injured spinal cord of rats.
Neural Regen Res, 2012 • July 1, 2012
This study formulates a mathematical model based on cell chemotaxis and uses a three-dimensional lattice Boltzmann method for numerical simulation to observe the effects of glial scar size and inhibit...
KEY FINDING: A larger glial scar and a higher release rate of inhibitor resulted in a reduced axonal growth rate.
Neural Regeneration Research, 2014 • December 1, 2014
This study demonstrated that blockade of SFK by PP2 after SCI resulted in an improved functional locomotor recovery using two behavioral assays. Moreover, the amount of spared tissue and serotonin fib...
KEY FINDING: Long-term blockade of SFK activation with PP2 increases locomotor activity at 7, 14, 21 and 28 days post-injury in the Basso, Beattie, and Bresnahan open field test, round and square beam crossing tests.